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Oxidative Stress

Effect of 900 MHz Electromagnetic Radiation on the Induction of ROS in Human Peripheral Blood Mononuclear Cells.

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Kazemi E, Mortazavi SM, Ali-Ghanbari A, Sharifzadeh S, Ranjbaran R, Mostafavi-Pour Z, Zal F, Haghani M. · 2015

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Exposure to 900 MHz GSM significantly increased ROS production in monocyte-rich peripheral blood mononuclear cells but not in lymphocyte-rich cells.

Plain English Summary

Summary written for general audiences

The study investigated the effect of 900 MHz GSM on oxidative stress and intracellular ROS levels in human mononuclear cells, monocytes, and lymphocytes. Blood samples from 13 healthy volunteers were exposed to RF radiation from a mobile phone simulator for 2 hours, while control samples were not exposed. Mononuclear cells were isolated by density gradient centrifugation and ROS was measured using a CM-H2DCFDA fluorescence probe and flow cytometry. Results showed a significant increase in ROS production in monocyte-rich cell populations after exposure, but no significant change in lymphocyte-rich populations.

Why This Matters

The authors concluded that RF electromagnetic fields can induce oxidative stress in PBMCs, particularly in monocytes, similar to the effect of microorganism exposure. They noted that the advantages or disadvantages of this effect should be evaluated further.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900 MHz Duration: 2 hr

Study Details

Here we investigated the effect of 900 MHz GSM on the induction of oxidative stress and the level of intracellular reactive oxygen species (ROS) in human mononuclear cells, monocytes and lymphocytes as defence system cells.

6 ml Peripheral Blood samples were obtained from 13 healthy volunteers (21-30 year-old). Each sample...

Our results showed significant increase in ROS production after exposure in population rich in monoc...

The results obtained in this study clearly showed the oxidative stress induction capability of RF electromagnetic field in the portion of PBMCs mostly in monocytes, like the case of exposure to micro organisms, although the advantages or disadvantages of this effect should be evaluated.

Cite This Study
Kazemi E, Mortazavi SM, Ali-Ghanbari A, Sharifzadeh S, Ranjbaran R, Mostafavi-Pour Z, Zal F, Haghani M. (2015). Effect of 900 MHz Electromagnetic Radiation on the Induction of ROS in Human Peripheral Blood Mononuclear Cells. J Biomed Phys Eng. 5(3):105-114, 2015.
Show BibTeX
@article{e_2015_effect_of_900_mhz_1655,
  author = {Kazemi E and Mortazavi SM and Ali-Ghanbari A and Sharifzadeh S and Ranjbaran R and Mostafavi-Pour Z and Zal F and Haghani M.},
  title = {Effect of 900 MHz Electromagnetic Radiation on the Induction of ROS in Human Peripheral Blood Mononuclear Cells.},
  year = {2015},
  
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576871/},
}

Quick Questions About This Study

The study used 900 MHz GSM radiation emitted from a mobile phone simulator for 2 hours.
The researchers analyzed ROS in monocyte-rich and lymphocyte-rich populations of peripheral blood mononuclear cells.
ROS production increased significantly in monocyte-rich populations but not in lymphocyte-rich populations compared to unexposed controls.
Intracellular ROS content was measured using the CM-H2DCFDA fluorescence probe and flow cytometry.
The researchers concluded that RF electromagnetic fields can induce oxidative stress in PBMCs, mainly in monocytes, similar to microorganism exposure, but the health implications need further evaluation.