Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence
Kim JH, Jeon S, Choi H-D, Lee J-H, Bae J-S, Kim N, Kim H-G, Kim K- B, Kim HR · 2021
Exposure to 1760 MHz RF-EMF at 4 W/kg SAR for 4 hours daily over 4 days significantly decreased SH-SY5Y cell proliferation, delayed the cell cycle in G0/G1 phase, and did not involve DNA damage or apoptosis.
Plain English Summary
Researchers exposed SH-SY5Y neuronal cells to 1760 MHz LTE RF-EMF at 4 W/kg SAR for 4 hours per day over 4 days. The exposure significantly reduced cell growth and proliferation and delayed the cell cycle in the G0/G1 phase. DNA damage and apoptosis were not involved, as γH2AX levels were not markedly altered and the apoptotic pathway was not activated. RF-EMF exposure significantly elevated Akt and mTOR phosphorylation and increased total and phosphorylated p53. Activated p53 increased p21 and p27 expression, inhibited CDK2 and CDK4, and reduced phosphorylated retinoblastoma, decreasing proliferation.
Why This Matters
The authors concluded that RF-EMF exposure might induce Akt/mTOR-mediated cellular senescence, which may delay the cell cycle without triggering DNA damage in SH-SY5Y neuroblastoma cells. They also suggested that Akt/mTOR-mediated cellular senescence led to p53 activation via stimulation of the mTOR pathway.
Show BibTeX
@article{kim_jh_jeon_s_choi_h_d_lee_j_h_bae_j_s_kim_n_kim_h_g_kim_k_b_kim_hr_ce2860,
author = {Kim JH and Jeon S and Choi H-D and Lee J-H and Bae J-S and Kim N and Kim H-G and Kim K- B and Kim HR},
title = {Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence},
year = {2021},
}