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Changes in numbers and size of synaptic vesicles of cortical neurons induced by exposure to 835 MHz radiofrequency-electromagnetic field

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Kim JH, Kim HJ, Yu DH, Kweon HS, Huh YH, Kim HR · 2017

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RF-EMF exposure at 835 MHz reduced synaptic vesicle density and synapsin expression in mouse cortical neurons, potentially affecting neurotransmitter availability at synapses.

Plain English Summary

Summary written for general audiences

This study examined the effects of 835 MHz radiofrequency electromagnetic field (RF-EMF) exposure on synaptic vesicles in cortical neurons of mice exposed to 4.0 W/kg SAR for 5 hours daily. The researchers found that RF-EMF exposure significantly decreased the density of synaptic vesicles in presynaptic terminals and reduced expression of synapsin I/II genes and proteins, suggesting potential alterations in neurotransmitter levels in the cerebral cortex.

Why This Matters

Synaptic vesicles and synapsins are critical components of synaptic neurotransmission, so alterations in their number or expression could theoretically impact neuronal signaling. The study used electron microscopy techniques that allow quantitative assessment of ultrastructural changes, though further investigation would be needed to establish functional consequences of these morphological findings.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Kim JH, Kim HJ, Yu DH, Kweon HS, Huh YH, Kim HR (2017). Changes in numbers and size of synaptic vesicles of cortical neurons induced by exposure to 835 MHz radiofrequency-electromagnetic field.
Show BibTeX
@article{kim_jh_kim_hj_yu_dh_kweon_hs_huh_yh_kim_hr_ce3307,
  author = {Kim JH and Kim HJ and Yu DH and Kweon HS and Huh YH and Kim HR},
  title = {Changes in numbers and size of synaptic vesicles of cortical neurons induced by exposure to 835 MHz radiofrequency-electromagnetic field},
  year = {2017},
  doi = {10.1016/S1470-2045(17)30186-9},
  
}
DOI: 10.1016/S1470-2045(17)30186-9PubMed: 29045446

Quick Questions About This Study

Childhood cancer rates increased 13% globally, rising from 124.0 cases per million children in the 1980s to 140.6 cases per million during 2001-2010, representing a significant upward trend across multiple countries and cancer types.
In children aged 0-14 years, leukemia was most common (46.4 cases per million), followed by central nervous system tumors (28.2 per million) and lymphomas (15.2 per million), based on data from 62 countries.
The study analyzed 385,509 childhood cancer cases from 153 cancer registries across 62 countries during 2001-2010, making it the largest international comparison of childhood cancer incidence rates ever conducted.
Yes, cancer incidence varied considerably between geographical regions, racial and ethnic groups, and by cancer type. The study found substantial differences in rates across the 19 geographical areas analyzed.
The increase spans from the 1980s through 2001-2010, a period that coincides with the widespread adoption of wireless technologies including early cell phones, cordless phones, and the beginning of WiFi deployment.