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Mutagenic response of 2.45 GHz radiation exposure on rat brain.

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Kesari KK, Behari J, Kumar S. · 2010

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Exposure to 2.45 GHz microwave radiation was associated with significant DNA damage in rat brain cells.

Plain English Summary

Summary written for general audiences

Researchers exposed male Wistar rats to 2.45 GHz microwave radiation for 2 hours a day for 35 days at a power density of 0.34 mW/cm2. The whole brain tissue was dissected and used for study of double strand DNA breaks by micro gel electrophoresis and comet assay. Exposed brain cells showed a significant increase in comet head, tail length, and tail movement. The study concluded that chronic exposure to these radiations may cause significant damage to brain, which may be an indication of possible tumour promotion.

Why This Matters

Male Wistar rats 35 days old and weighing 130 ± 10 g were divided into a sham-exposed control group and an experimental group. The whole body specific absorption rate during exposure was estimated to be 0.11 W/Kg. Antioxidant enzymes and histone kinase estimation was also performed after the exposure period. Glutathione peroxidase and superoxide dismutase decreased significantly in exposed animals, while catalase increased. A significant decrease in histone kinase was also recorded in the exposed group as compared to the control sham-exposed ones.

Exposure Details

SAR
0.11 W/kg
Power Density
0.34 mW/cm²
Source/Device
2.45 GHz
Exposure Duration
2 h a day for 35 days

Exposure Context

This study used 0.34 mW/cm² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.34 mW/cm²Extreme Concern - 1,000 µW/m²FCC Limit - 10M µW/m²Effects observed in the Extreme Concern range (Building Biology)FCC limit is 3 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

To investigate the effect of 2.45 GHz microwave radiation on rat brain of male wistar strain.

Male rats of wistar strain (35 days old with 130 ± 10 g body weight) were selected for this study. A...

A significant increase was observed in comet head (P < 0.002), tail length (P < 0.0002) and in tail ...

The study concludes that the chronic exposure to these radiations may cause significant damage to brain, which may be an indication of possible tumour promotion (Behari and Paulraj ).

Cite This Study
Kesari KK, Behari J, Kumar S. (2010). Mutagenic response of 2.45 GHz radiation exposure on rat brain. Int J Radiat Biol 86:334-343, 2010.
Show BibTeX
@article{kk_2010_mutagenic_response_of_245_8,
  author = {Kesari KK and Behari J and Kumar S.},
  title = {Mutagenic response of 2.45 GHz radiation exposure on rat brain.},
  year = {2010},
  doi = {10.3109/09553000903564059},
  url = {http://informahealthcare.com/doi/abs/10.3109/09553000903564059},
}
DOI: 10.3109/09553000903564059

Cited By (84 papers)

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Quick Questions About This Study

Male Wistar rats were used and exposed for 2 hours a day for 35 days to 2.45 GHz frequency at 0.34 mW/cm2 power density.
Exposed brain cells showed a significant increase in comet head, tail length, and tail movement.
Glutathione peroxidase and superoxide dismutase showed a decrease, while an increase in catalase was observed.
The study concluded that chronic exposure to these radiations may cause significant damage to brain, which may be an indication of possible tumour promotion.
The whole body specific absorption rate was estimated to be 0.11 W/Kg.