Extremely low-frequency electromagnetic fields facilitate both osteoblast and osteoclast activity through Wnt/β-catenin signaling in the zebrafish scale
Kobayashi- Sun J, Kobayashi I, Kashima M, Hirayama J, Kakikawa M, Yamada S, Suzuki N · 2024
Exposure to 10 mT ELF-EMFs at 60 Hz increased both osteoblast and osteoclast numbers in zebrafish scale fractures, an effect dependent on Wnt/β-catenin signaling.
Plain English Summary
Researchers used zebrafish scales as an in vivo model to study the effects of extremely low-frequency electromagnetic fields on fracture healing. Exposure to 10 mT ELF-EMFs at 60 Hz increased the numbers of both osteoblasts and osteoclasts at the fracture site, while 3 mT and 30 mT did not. The exposure also upregulated wnt10b and Wnt target genes and enhanced β-catenin expression at the fracture site. Inhibition of Wnt/β-catenin signaling by IWR-1-endo treatment reduced both osteoblasts and osteoclasts in the fractured scale exposed to ELF-EMFs.
Why This Matters
Electromagnetic fields have received widespread attention as effective, noninvasive, and safe therapies for bone disorders, but varying device frequencies have made it hard to understand their effects on bone tissue. The ELF-EMFs in this study were generated using a widely used commercial AC power supply. The findings suggest that ELF-EMFs promote both osteoblast and osteoclast activity through activation of Wnt/β-catenin signaling in fracture healing.
Show BibTeX
@article{kobayashi_sun_j_kobayashi_i_kashima_m_hirayama_j_kakikawa_m_yamada_s_suzuki_n_ce4084,
author = {Kobayashi- Sun J and Kobayashi I and Kashima M and Hirayama J and Kakikawa M and Yamada S and Suzuki N},
title = {Extremely low-frequency electromagnetic fields facilitate both osteoblast and osteoclast activity through Wnt/β-catenin signaling in the zebrafish scale},
year = {2024},
}