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Effects of 2.45-GHz electromagnetic fields with a wide range of SARs on micronucleus formation in CHO-K1 cells.

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Koyama S, Isozumi Y, Suzuki Y, Taki M, Miyakoshi J. · 2004

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Micronucleus formation in CHO-K1 cells increased only at SARs of 100 and 200 W/kg, and researchers suggested this may be linked to the rise in temperature those exposure levels cause.

Plain English Summary

Summary written for general audiences

Researchers exposed Chinese hamster ovary CHO-K1 cells to 2.45-GHz electromagnetic fields for 2 hours at SARs of 5, 10, 20, 50, 100, and 200 W/kg to study micronucleus formation. Micronucleus frequency in cells exposed at SARs lower than 50 W/kg did not differ from sham-exposed controls. At SARs of 100 and 200 W/kg, micronucleus frequency was significantly higher than in sham-exposed controls. The researchers also found that micronucleus frequency increased in a temperature-dependent manner when cells were heat-treated at temperatures from 38 to 42 degrees C.

Why This Matters

Micronucleus formation is induced by chromosomal breakage or inhibition of spindles during cell division and leads to cell damage. Because electromagnetic field exposure raises temperature, the researchers also examined heat's influence on micronucleus formation separately. The researchers suggested that the rise in temperature caused by higher SARs may be connected to the increase in micronucleus formation observed. Cells were also treated with bleomycin alone as a positive control or with a combined treatment of electromagnetic field exposure and bleomycin. There was no apparent combined effect of electromagnetic field exposure and bleomycin treatment.

Exposure Details

SAR
5, 10, 20, 50, 100, and 200 W/kg
Source/Device
2.45-GHz
Exposure Duration
2 hours

Exposure Context

This study used 5, 10, 20, 50, 100, and 200 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 5, 10, 20, 50, 100, and 200 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 3 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

In order to investigate the properties of HFEMF, we have examined the effects of 2.45-GHz EMF on micronucleus (MN) formation in Chinese hamster ovary (CHO)-K1 cells.

MN formation is induced by chromosomal breakage or inhibition of spindles during cell division and l...

The MN frequency in cells exposed to HFEMF at a SAR of lower than 50 W/kg did not differ from the sh...

Cite This Study
Koyama S, Isozumi Y, Suzuki Y, Taki M, Miyakoshi J. (2004). Effects of 2.45-GHz electromagnetic fields with a wide range of SARs on micronucleus formation in CHO-K1 cells. ScientificWorldJournal 4 Suppl 2:29-40, 2004.
Show BibTeX
@article{s_2004_effects_of_245ghz_electromagnetic_1110,
  author = {Koyama S and Isozumi Y and Suzuki Y and Taki M and Miyakoshi J.},
  title = {Effects of 2.45-GHz electromagnetic fields with a wide range of SARs on micronucleus formation in CHO-K1 cells.},
  year = {2004},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/15517100/},
}
PubMed: 15517100

Cited By (50 papers)

Quick Questions About This Study

Micronucleus frequency was significantly higher than sham controls only at SARs of 100 and 200 W/kg.
Micronucleus frequency in cells exposed at SARs lower than 50 W/kg did not differ from sham-exposed controls.
Micronucleus frequency increased in a temperature-dependent manner when cells were heat-treated at temperatures from 38 to 42 degrees C.
There was no apparent combined effect of electromagnetic field exposure and bleomycin treatment.
The study used Chinese hamster ovary CHO-K1 cells exposed to 2.45-GHz electromagnetic fields.