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Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel

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Li J, Guo H, Tan L, Chen M, Wang X, Liu Y, Chen S, Wang Y, Yu H, Wang P · 2025

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Terahertz irradiation promotes angiogenesis in endothelial cells primarily through voltage-gated calcium channel activation and VEGF signaling pathway stimulation.

Plain English Summary

Summary written for general audiences

This study examined how terahertz (THz) radiation at 2.52 THz frequency affects human umbilical vein endothelial cells (HUVECs) in vitro. The researchers found that THz irradiation significantly enhanced the cells' angiogenic capacity by increasing intracellular calcium levels and upregulating angiogenesis-related proteins like VEGF, though it did not affect cell proliferation.

Why This Matters

This research contributes to understanding THz bioeffects at the molecular level, focusing on a non-thermal mechanism involving calcium signaling. The findings are relevant to potential medical applications of THz technology, though in vitro results require validation in vivo before clinical significance can be assessed.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Li J, Guo H, Tan L, Chen M, Wang X, Liu Y, Chen S, Wang Y, Yu H, Wang P (2025). Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel.
Show BibTeX
@article{li_j_guo_h_tan_l_chen_m_wang_x_liu_y_chen_s_wang_y_yu_h_wang_p_ce2900,
  author = {Li J and Guo H and Tan L and Chen M and Wang X and Liu Y and Chen S and Wang Y and Yu H and Wang P},
  title = {Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel},
  year = {2025},
  
  
}
PubMed: 39982926

Quick Questions About This Study

Yes, this 2025 study found that 2.52 THz radiation significantly boosted angiogenesis (new blood vessel formation) in human umbilical vein endothelial cells. The exposure increased intracellular calcium levels and upregulated VEGF, a key protein that drives blood vessel growth, without affecting overall cell numbers.
The study found that 2.52 THz terahertz radiation enhanced the permeability of voltage-gated calcium channels in endothelial cells, allowing more calcium to enter the cells. This increased intracellular calcium appears to be the mechanism driving the observed boost in angiogenic activity.
No, the researchers specifically found that 2.52 THz radiation did not affect cell proliferation in human umbilical vein endothelial cells. The biological effect was limited to enhancing angiogenic capacity through calcium signaling and VEGF upregulation, not increasing cell division rates.
This in vitro study found that 2.52 THz terahertz irradiation upregulated VEGF (vascular endothelial growth factor), a protein essential for new blood vessel growth. This increase in angiogenesis related proteins occurred alongside enhanced calcium channel permeability in the exposed endothelial cells.
Yes, this 2025 in vitro study exposed human umbilical vein endothelial cells (HUVECs) to 2.52 THz radiation and found significant biological effects. The cells showed enhanced angiogenic capacity through increased calcium influx and higher VEGF expression, though cell proliferation remained unchanged.