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Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel

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Li J, Guo H, Tan L, Chen M, Wang X, Liu Y, Chen S, Wang Y, Yu H, Wang P · 2025

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Terahertz irradiation promotes angiogenesis in endothelial cells primarily through voltage-gated calcium channel activation and VEGF signaling pathway stimulation.

Plain English Summary

Summary written for general audiences

This study examined how terahertz (THz) radiation at 2.52 THz frequency affects human umbilical vein endothelial cells (HUVECs) in vitro. The researchers found that THz irradiation significantly enhanced the cells' angiogenic capacity by increasing intracellular calcium levels and upregulating angiogenesis-related proteins like VEGF, though it did not affect cell proliferation.

Why This Matters

This research contributes to understanding THz bioeffects at the molecular level, focusing on a non-thermal mechanism involving calcium signaling. The findings are relevant to potential medical applications of THz technology, though in vitro results require validation in vivo before clinical significance can be assessed.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Li J, Guo H, Tan L, Chen M, Wang X, Liu Y, Chen S, Wang Y, Yu H, Wang P (2025). Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel.
Show BibTeX
@article{li_j_guo_h_tan_l_chen_m_wang_x_liu_y_chen_s_wang_y_yu_h_wang_p_ce2900,
  author = {Li J and Guo H and Tan L and Chen M and Wang X and Liu Y and Chen S and Wang Y and Yu H and Wang P},
  title = {Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel},
  year = {2025},
  doi = {10.1038/s41586-025-09422-z},
  
}
DOI: 10.1038/s41586-025-09422-zPubMed: 39982926

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