Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel
Li J, Guo H, Tan L, Chen M, Wang X, Liu Y, Chen S, Wang Y, Yu H, Wang P · 2025
Terahertz irradiation at 2.52 THz enhanced angiogenesis in human umbilical vein endothelial cells without affecting proliferation.
Plain English Summary
Researchers exposed human umbilical vein endothelial cells to terahertz irradiation at 2.52 THz and 100 mW/cm2. The irradiation did not alter proliferation but significantly enhanced angiogenic capacity. VEGF levels increased in the culture supernatant, and cytoskeleton-associated genes PDXP and SH3BP1 were upregulated. Intracellular calcium concentration markedly increased, and diltiazem mitigated the angiogenic enhancement.
Why This Matters
Terahertz waves are positioned between microwave and infrared and have promising applications in medical imaging and biomedicine. The authors conclude that terahertz irradiation promotes angiogenesis in HUVECs partly by activating the VEGF signaling pathway through increased calcium fluxes.
Show BibTeX
@article{li_j_guo_h_tan_l_chen_m_wang_x_liu_y_chen_s_wang_y_yu_h_wang_p_ce2900,
author = {Li J and Guo H and Tan L and Chen M and Wang X and Liu Y and Chen S and Wang Y and Yu H and Wang P},
title = {Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel},
year = {2025},
}