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Oxidative Stress

Hsp70 expression and free radical release after exposure to non-thermal radio-frequency electromagnetic fields and ultrafine particles in human Mono Mac 6 cells.

No Effects Found

Simkó M, Hartwig C, Lantow M, Lupke M, Mattsson MO, Rahman Q, Rollwitz J. · 2006

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RF exposure alone or combined with ultrafine particles did not affect free radical levels or Hsp70 expression in human Mono Mac 6 cells.

Plain English Summary

Summary written for general audiences

The study investigated Hsp70 expression and free radical release in human Mono Mac 6 cells exposed to ultrafine particles and radiofrequency electromagnetic fields. Ultrafine particle exposure increased free radical release by 40-45% above negative control, an effect stronger than heat treatment. Radiofrequency electromagnetic field exposure alone did not change free radical levels. Combined exposure to RF and ultrafine particles did not enhance the particle effect on free radicals. Heat treatment increased Hsp70 expression in a time-dependent manner, while ultrafine particles, RF fields, or their combination had no effect on Hsp70.

Why This Matters

Researchers used ultrafine particles of 12-14 nm at 100 µg/ml and RF-EMF at 2 W/kg SAR with continuous wave or modulated signals at 217 Hz or GSM-nonDTX. Heat treatment at 42-43°C for 1 hour served as a positive control for stress response and for heat development in the RF exposure setup. The authors concluded that RF exposure alone or with ultrafine particles cannot influence stress-related responses in these cells.

Exposure Details

SAR
2 W/kg
Source/Device
217Hz

Exposure Context

This study used 2 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 2 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 217 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 217 HzPower lines50/60 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The aim of the present study was to investigate Hsp70 expression and free radical release after exposure to non-thermal radio-frequency electromagnetic fields and ultrafine particles in human Mono Mac 6 cells

we investigate if exposure to UFP (12-14 nm, 100 microg/ml) and RF-electromagnetic fields (EMF; 2 W/...

Our results clearly show that Mono Mac 6 cells are capable to internalise UFP, and that this phagocy...

Therefore, we conclude that in the investigated Mono Mac 6 cells, RF exposure alone or in combination with UFP cannot influence stress-related responses.

Cite This Study
Simkó M, Hartwig C, Lantow M, Lupke M, Mattsson MO, Rahman Q, Rollwitz J. (2006). Hsp70 expression and free radical release after exposure to non-thermal radio-frequency electromagnetic fields and ultrafine particles in human Mono Mac 6 cells. Toxicol Lett. (1):73-82, 2006.
Show BibTeX
@article{m_2006_hsp70_expression_and_free_2889,
  author = {Simkó M and Hartwig C and Lantow M and Lupke M and Mattsson MO and Rahman Q and Rollwitz J.},
  title = {Hsp70 expression and free radical release after exposure to non-thermal radio-frequency electromagnetic fields and ultrafine particles in human Mono Mac 6 cells.},
  year = {2006},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/16153791/},
}
PubMed: 16153791

Cited By (98 papers)

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Quick Questions About This Study

Ultrafine particles increased free radical release by 40-45% above negative control, an effect stronger than heat treatment.
None of the RF exposures showed any effects on free radical levels.
Co-exposure of RF and UFP did not potentiate the UFP effect on free radical release.
Heat treatment increased Hsp70 expression in a time-dependent manner, while ultrafine particles, RF fields, or their combination had no effect.
Cells were exposed to ultrafine particles of 12-14 nm at 100 µg/ml and RF-EMF at 2 W/kg SAR with continuous wave or modulated signals at 217 Hz or GSM-nonDTX.