Note: This study found no significant biological effects under its experimental conditions. We include all studies for scientific completeness.
Nuclear translocation and DNA-binding activity of NFKB (NF-kappaB) after exposure of human monocytes to pulsed ultra-wideband electromagnetic fields (1 kV/cm) fails to transactivate kappaB-dependent gene expression.
Natarajan M, Nayak BK, Galindo C, Mathur SP, Roldan FN, Meltz ML · 2006
View Original AbstractUltra-high EMF exposure triggered cellular stress signals but failed to produce actual biological responses, suggesting initial activation doesn't guarantee health effects.
Plain English Summary
Researchers exposed human immune cells to extremely powerful pulsed electromagnetic fields (1,000 times stronger than typical EMF exposures) for 90 minutes and found that while the fields initially activated a key cellular stress response called NF-kappaB, this activation was functionally meaningless - it didn't actually trigger the downstream immune responses that normally follow. The study suggests that even very high EMF exposures may not necessarily translate into biological consequences.
Study Details
The objective of this study was to investigate whether exposure of human monocytes to a pulsed ultra-wideband electromagnetic field (EMF) of 1 kV/cm average peak power triggers a signaling pathway responsible for the transcriptional regulation of NFKB (NF-kappaB)-dependent gene expression.
Human Mono Mac 6 (MM6) cells were exposed intermittently to EMF pulses for a total of 90 min. The pu...
Cells exposed to the EMFs and incubated for 24 h postexposure showed a 3.5+/-0.2-fold increase in th...
From these results, it is clear that the EMF-induced NFKB activation is only a transient response, with minimal or no downstream effect.
Show BibTeX
@article{m_2006_nuclear_translocation_and_dnabinding_3269,
author = {Natarajan M and Nayak BK and Galindo C and Mathur SP and Roldan FN and Meltz ML},
title = {Nuclear translocation and DNA-binding activity of NFKB (NF-kappaB) after exposure of human monocytes to pulsed ultra-wideband electromagnetic fields (1 kV/cm) fails to transactivate kappaB-dependent gene expression.},
year = {2006},
url = {https://pubmed.ncbi.nlm.nih.gov/16802864/},
}