Effect of 7 mT static magnetic field and iron ions on rat lymphocytes: apoptosis, necrosis and free radical processes.
Jajte J, Grzegorczyk J, Zmyślony M, Rajkowska E. · 2002
View Original AbstractRat lymphocytes exposed to a 7 mT static magnetic field combined with iron ions showed significantly increased apoptosis and necrosis, while the field alone had no effect.
Plain English Summary
Researchers exposed rat blood lymphocytes to a 7 mT static magnetic field for 3 hours in Helmholtz coils, with some samples also treated with ferrous chloride at 10 μg/ml. The static magnetic field alone and iron ions alone each produced no significant effect on cell viability. When the field and iron ions were combined, there was a significant increase in apoptotic and necrotic cells and significant alterations in cell viability. The researchers suggested that a 7 mT static magnetic field in the presence of Fe2+ ions can increase the concentration of oxygen free radicals and thus may lead to cell death.
Why This Matters
The study was designed to ask whether oxidative DNA damage from combined exposure to the magnetic field and iron ions could lead to apoptosis or necrosis in rat lymphocytes. Cell death was detected using a dye exclusion method with the DNA-fluorochromes ethidium bromide and acridine orange. Neither the magnetic field alone nor iron ions alone caused significant changes, but their combination produced significant increases in apoptotic and necrotic cells. Alongside cell death, there was a significant increase in lipid peroxidation end products MDA+4 HNE in lymphocytes exposed simultaneously to the field and iron ions, compared to control samples and those exposed to the field alone.
Exposure Details
- Magnetic Field
- 7 mT
- Exposure Duration
- 3h
Exposure Context
This study used 7 mT for magnetic fields:
- 350Kx above the Building Biology guideline of 0.2 mG
- 70Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
To study whether the oxidative DNA damage caused by simultaneous exposure of rat lymphocytes to a 7 mT static magnetic field and iron ions may lead to cell death: apoptosis or necrosis.
Experiments were performed on rat blood lymphocytes incubated for 3 h in Helmholtz coils at SMF of f...
No significant differences were observed between unexposed lymphocytes incubated with medium alone a...
This suggests that 7 mT static magnetic field in the presence of Fe2+ ions can increase the concentration of oxygen free radicals and thus may lead to cell death.
Show BibTeX
@article{j_2002_effect_of_7_mt_389,
author = {Jajte J and Grzegorczyk J and Zmyślony M and Rajkowska E.},
title = {Effect of 7 mT static magnetic field and iron ions on rat lymphocytes: apoptosis, necrosis and free radical processes.},
year = {2002},
url = {https://www.sciencedirect.com/science/article/abs/pii/S1567539402000592},
}