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Effect of a chronic GSM 900MHz exposure on glia in the rat brain.

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Ammari M, Brillaud E, Gamez C, Lecomte A, Sakly M, Abdelmelek H, de Seze R. · 2008

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Chronic cell phone radiation exposure triggered persistent brain inflammation in rats at levels higher than typical phone use.

Plain English Summary

Summary written for general audiences

French researchers exposed rats to cell phone radiation (900 MHz) for 24 weeks and found that high-level exposure caused persistent brain inflammation. The study measured GFAP, a protein that increases when brain support cells called astrocytes become activated in response to injury or stress. This suggests that chronic cell phone radiation exposure may trigger ongoing inflammatory responses in brain tissue.

Why This Matters

This research adds to mounting evidence that radiofrequency radiation can trigger neuroinflammation, a process linked to various neurological conditions. The 6 W/kg exposure level used here is significantly higher than typical cell phone use (which averages 1-2 W/kg), but the fact that researchers observed persistent glial activation 10 days after exposure ended is particularly concerning. Glial cells are the brain's immune system, and chronic activation suggests the brain interpreted the RF exposure as a threat requiring ongoing defensive response. What makes this study especially relevant is that it examined chronic exposure over nearly six months, better reflecting real-world usage patterns than acute studies. The reality is that we're conducting an unprecedented experiment on human brains with devices we use for hours daily, and studies like this suggest our neural tissue may be responding in ways we're only beginning to understand.

Exposure Details

SAR
6 W/kg
Source/Device
900-MHz
Exposure Duration
15 min/day for 5 days a week for 24 weeks

Exposure Context

This study used 6 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 6 W/kgExtreme Concern0.1 W/kgFCC Limit1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 0x higher than this exposure level

Study Details

The aim of this study is to observe Effect of a chronic GSM 900MHz exposure on glia in the rat brain.

In this study we measured GFAP expression using immunocytochemistry method, to evaluate glial evolut...

In comparison to sham or cage control animals, rats exposed to chronic GSM signal at 6 W/kg have inc...

Our results indicated that chronic exposure to GSM 900 MHz microwaves (SAR = 6 W/kg) may induce persistent astroglia activation in the rat brain (sign of a potential gliosis).

Cite This Study
Ammari M, Brillaud E, Gamez C, Lecomte A, Sakly M, Abdelmelek H, de Seze R. (2008). Effect of a chronic GSM 900MHz exposure on glia in the rat brain. Biomed Pharmacother. 62(4):273-281, 2008.
Show BibTeX
@article{m_2008_effect_of_a_chronic_810,
  author = {Ammari M and Brillaud E and Gamez C and Lecomte A and Sakly M and Abdelmelek H and de Seze R.},
  title = {Effect of a chronic GSM 900MHz exposure on glia in the rat brain.},
  year = {2008},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0753332208000619},
}

Quick Questions About This Study

French researchers exposed rats to cell phone radiation (900 MHz) for 24 weeks and found that high-level exposure caused persistent brain inflammation. The study measured GFAP, a protein that increases when brain support cells called astrocytes become activated in response to injury or stress. This suggests that chronic cell phone radiation exposure may trigger ongoing inflammatory responses in brain tissue.