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Mobile phone use and glioma risk: A systematic review and meta-analysis.

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Yang M, Guo W, Yang C, Tang J, Huang Q, Feng S, Jiang A, Xu X, Jiang G. · 2017

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A meta-analysis of 11 studies found a significant positive association between long-term mobile phone use of at least 10 years and glioma risk (OR = 1.44, 95% CI = 1.08-1.91).

Plain English Summary

Summary written for general audiences

Researchers conducted a systematic review and meta-analysis of 11 studies with 6028 cases and 11488 controls to investigate mobile phone use and glioma risk. Long-term mobile phone use of at least 10 years showed a significant positive association with glioma (OR = 1.44, 95% CI = 1.08-1.91). Long-term ipsilateral use was also associated with glioma (OR = 1.46, 95% CI = 1.12-1.92), while contralateral use was not associated regardless of duration. Long-term use was associated with 2.22 times greater odds of low-grade glioma (OR = 2.22, 95% CI = 1.69-2.92), but mobile phone use of any duration was not associated with high-grade glioma (OR = 0.81, 95% CI = 0.72-0.92).

Why This Matters

The authors used a random effects model to extract odds ratios and 95% confidence intervals and performed subgroup analyses. They noted that current evidence is of poor quality and limited quantity, and called for large sample, high quality research to better characterize any potential association. The results suggest that long-term mobile phone use may be associated with an increased risk of glioma, with an association also seen for low-grade glioma in regular or long-term use subgroups. The association was not observed when the analysis was limited to high-grade glioma.

Study Details

Many studies have previously investigated the potential association between mobile phone use and the risk of glioma. However, results from these individual studies are inconclusive and controversial. The objective of our study was to investigate the potential association between mobile phone use and subsequent glioma risk using meta-analysis.

We performed a systematic search of the Science Citation Index Embase and PubMed databases for studi...

There was a significant positive association between long-term mobile phone use (minimum, 10 years) ...

Our results suggest that long-term mobile phone use may be associated with an increased risk of glioma. There was also an association between mobile phone use and low-grade glioma in the regular use or long-term use subgroups. However, current evidence is of poor quality and limited quantity. It is therefore necessary to conduct large sample, high quality research or better characterization of any potential association between long-term ipsilateral mobile phone use and glioma risk.

Cite This Study
Yang M, Guo W, Yang C, Tang J, Huang Q, Feng S, Jiang A, Xu X, Jiang G. (2017). Mobile phone use and glioma risk: A systematic review and meta-analysis. PLoS One. 12(5):e0175136, 2017.
Show BibTeX
@article{m_2017_mobile_phone_use_and_2690,
  author = {Yang M and Guo W and Yang C and Tang J and Huang Q and Feng S and Jiang A and Xu X and Jiang G.},
  title = {Mobile phone use and glioma risk: A systematic review and meta-analysis.},
  year = {2017},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/28472042/},
}
PubMed: 28472042

Cited By (82 papers)

View all 82 citing papers on Semantic Scholar

Quick Questions About This Study

Long-term mobile phone use of at least 10 years was significantly associated with glioma (OR = 1.44, 95% CI = 1.08-1.91).
Long-term ipsilateral use was associated with glioma (OR = 1.46, 95% CI = 1.12-1.92), while contralateral use was not associated regardless of duration.
Long-term use was associated with 2.22 times greater odds of low-grade glioma (OR = 2.22, 95% CI = 1.69-2.92), but mobile phone use of any duration was not associated with high-grade glioma (OR = 0.81, 95% CI = 0.72-0.92).
The authors stated that current evidence is of poor quality and limited quantity, and that large sample, high quality research is needed to better characterize any potential association.
The meta-analysis included 11 studies with a total of 6028 cases and 11488 controls.