Magnetic field-induced changes in specific gene transcription
Authors not listed · 1992
Exposure to a 60 Hz magnetic field caused time-dependent and cell density-dependent changes in transcription of c-fos, c-jun, c-myc, and protein kinase C beta-form in CEM-CM3 T-lymphoblastoid cells.
Plain English Summary
Researchers used a nuclear run-off assay to measure specific gene transcription in CEM-CM3 T-lymphoblastoid cells exposed to a 1 gauss, 60 Hz sinusoidal magnetic field for 15 to 120 minutes. They observed time-dependent and cell density-dependent changes in the transcription of c-fos, c-jun, c-myc, and protein kinase C beta-form. Slot-blot analysis showed that changes in transcript levels paralleled the changes in gene transcription.
Why This Matters
The authors note that magnetic fields are physical environmental agents shown to produce various responses in cellular and animal studies, including general changes in gene transcription. They conclude that the data suggest an important role for magnetic field exposure in altering cellular processes.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{magnetic_field_induced_changes_in_specific_gene_transcription_ce1618,
author = {Unknown},
title = {Magnetic field-induced changes in specific gene transcription},
year = {1992},
doi = {10.1016/0167-4781(92)90004-J},
}