Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats
Authors not listed · 2005
Nocturnal melatonin-rich blood inhibited breast cancer xenograft growth, but brief light-at-night exposure abolished this effect.
Plain English Summary
Researchers exposed rats bearing human breast cancer xenografts to increasing intensities of white fluorescent light during the dark phase and collected blood from premenopausal women at daytime, nighttime, or after 90 minutes of bright light at night. Tumors perfused with nocturnal melatonin-rich blood showed markedly suppressed proliferative activity and linoleic acid uptake compared with tumors perfused with daytime melatonin-deficient blood. Tumors perfused with blood collected after ocular light-at-night exposure exhibited the daytime pattern of high tumor proliferative activity, and the tumor growth response to light during darkness was intensity dependent.
Show BibTeX
@article{melatonin_depleted_blood_from_premenopausal_women_exposed_to_light_at_night_stimulates_growth_of_human_breast_cancer_xenografts_in_nude_rats_ce1460,
author = {Unknown},
title = {Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats},
year = {2005},
doi = {10.1158/0008-5472.CAN-05-1945},
}