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Modulation of inflammatory response by electromagnetic field in Neuronal and Microglial cells

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Mendoza-Mari Y, Stojanovic M, Miulli DE, Agrawal DK · 2025

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Low-frequency EMF stimulation appeared to suppress pro-inflammatory gene expression in cultured neurons and microglial cells, suggesting a potential therapeutic approach for neuroinflammation-related conditions.

Plain English Summary

Summary written for general audiences

This in vitro study examined how low-frequency electromagnetic fields (EMF) affect inflammatory responses in neuronal and microglial cells treated with tumor necrosis factor-α. The researchers found that EMF exposure reduced pro-inflammatory marker expression in both cell types at 24 and 48 hours, supporting previous observations of EMF's anti-inflammatory effects in a traumatic brain injury animal model.

Why This Matters

The study bridges in vivo findings from a swine traumatic brain injury model with controlled in vitro experiments on individual cell types to characterize cellular-level mechanisms. The authors acknowledge that further preclinical and clinical research is needed to establish optimal EMF parameters for therapeutic application.

Exposure Information

Specific exposure levels were not quantified in this study.

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Cite This Study
Mendoza-Mari Y, Stojanovic M, Miulli DE, Agrawal DK (2025). Modulation of inflammatory response by electromagnetic field in Neuronal and Microglial cells.
Show BibTeX
@article{mendoza_mari_y_stojanovic_m_miulli_de_agrawal_dk_ce4147,
  author = {Mendoza-Mari Y and Stojanovic M and Miulli DE and Agrawal DK},
  title = {Modulation of inflammatory response by electromagnetic field in Neuronal and Microglial cells},
  year = {2025},
  doi = {10.1093/bjs/znaf005},
  
}
DOI: 10.1093/bjs/znaf005PubMed: 40778000

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