Modulation of inflammatory response by electromagnetic field in Neuronal and Microglial cells
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Mendoza-Mari Y, Stojanovic M, Miulli DE, Agrawal DK · 2025
Low-frequency EMF reduced pro-inflammatory gene expression in two cell lines treated with TNF-α.
Plain English Summary
Summary written for general audiences
The researchers used an in vitro model treating two cell lines with TNF-α and then stimulating them with two frequencies of low-frequency EMF. Both cell lines reduced target gene levels after EMF exposure, indicating an anti-inflammatory effect.
Why This Matters
The authors note that neuroinflammation is central to CNS pathologies. They conclude that further preclinical and clinical studies are needed to define the effective frequency and duration of EMF stimulation for brain injury healing.
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Cite This Study
Mendoza-Mari Y, Stojanovic M, Miulli DE, Agrawal DK (2025). Modulation of inflammatory response by electromagnetic field in Neuronal and Microglial cells.
Show BibTeX
@article{mendoza_mari_y_stojanovic_m_miulli_de_agrawal_dk_ce4147,
author = {Mendoza-Mari Y and Stojanovic M and Miulli DE and Agrawal DK},
title = {Modulation of inflammatory response by electromagnetic field in Neuronal and Microglial cells},
year = {2025},
}Quick Questions About This Study
The study used two different cell lines representing neurons and microglial cells.
Cells were stimulated with two frequencies of low-frequency electromagnetic field after TNF-α treatment.
Both cell lines reduced the levels of target genes after EMF exposure, supporting an anti-inflammatory effect.
Further preclinical and clinical studies are needed to determine the effective frequency and duration of EMF stimulation for brain injury healing.
The authors state that the anti-inflammatory effect of EMF has been observed in vivo in experimental animals and humans.