Metformin represses the carcinogenesis potentially induced by 50 Hz magnetic fields in aged mouse fibroblasts via inhibition of NF-kB
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Authors not listed
Metformin dose-dependently reduced proliferation and viability of aged mouse fibroblasts exposed to a 50 Hz magnetic field, lowered NF-kB and MMP2/9 expression, and raised CDH1 expression.
Plain English Summary
Summary written for general audiences
The study used an in vitro model of aged mouse NIH/3T3 fibroblasts exposed to a 5 mT, 50 Hz magnetic field and treated with metformin at four concentrations. Cell viability was measured with a trypan blue exclusion assay and proliferation with a BrdU incorporation assay. Metformin suppressed proliferation and viability in a dose-dependent manner, reduced NF-kB and MMP2/9 expression, increased CDH1 expression, and inhibited NF-kB activity.
Exposure Information
Specific exposure levels were not quantified in this study.
Cite This Study
Unknown (n.d.). Metformin represses the carcinogenesis potentially induced by 50 Hz magnetic fields in aged mouse fibroblasts via inhibition of NF-kB.
Show BibTeX
@article{metformin_represses_the_carcinogenesis_potentially_induced_by_50_hz_magnetic_fields_in_aged_mouse_fibroblasts_via_inhibition_of_nf_kb_ce4217,
author = {Unknown},
title = {Metformin represses the carcinogenesis potentially induced by 50 Hz magnetic fields in aged mouse fibroblasts via inhibition of NF-kB},
year = {n.d.},
doi = {10.1111/jcmm.70132},
}Quick Questions About This Study
The study used aged mouse NIH/3T3 fibroblasts.
Cells were exposed to a 5 mT, 50 Hz magnetic field.
Viability was measured with a trypan blue exclusion assay and proliferation with a BrdU incorporation assay.
Metformin suppressed both proliferation and viability in a dose-dependent manner, with the greatest inhibition at 10 mM.
Metformin reduced NF-kB and MMP2/9 expression, increased CDH1 expression, and suppressed NF-kB activity.