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The effects of long-term exposure to a 2450 MHz electromagnetic field on growth and pubertal development in female Wistar rats.

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Sangun O, Dundar B, Darici H, Comlekci S, Doguc DK, Celik S · 2015

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Prenatal exposure to 2450 MHz EMF resulted in postnatal growth restriction and delayed puberty in female Wistar rats.

Plain English Summary

Summary written for general audiences

Researchers exposed female Wistar rats to a 2450 MHz electromagnetic field for one hour per day starting either prenatally or postnatally, with a sham-exposed control group. Prenatal exposure led to significantly lower daily mass gain and significantly later puberty. Brain and ovary total oxidant status and oxidative stress index were significantly increased in the prenatal group compared to the control group. Serum LH levels were increased in both prenatal and postnatal groups, while FSH and E2 did not differ among groups. Histological examinations showed no statistically significant differences between groups.

Why This Matters

The study monitored growth, nutrition, and vaginal opening regularly and collected serum and tissue specimens at puberty. Researchers measured total antioxidant status, total oxidant status, oxidative stress index in ovary and brain tissues, performed immunohistochemical staining of the hypothalamus, and determined serum FSH, LH, E2, and IGF-1 values. Birth masses were similar across groups.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 2450 MHz Duration: 1 h/day

Study Details

The aim of this study was to investigate the effects of a 2450 MHz electromagnetic field (EMF) (wireless internet frequency) on the growth and development of female Wistar rats.

The study was conducted on three groups of rats. The prenatal and postnatal groups were exposed to E...

Birth masses of the groups were similar (p > 0.05). Mass gain per day was significantly lower and th...

This is the first longitudinal study which investigates the effects of EMF induced by wireless internet on pubertal development beside growth.

Cite This Study
Sangun O, Dundar B, Darici H, Comlekci S, Doguc DK, Celik S (2015). The effects of long-term exposure to a 2450 MHz electromagnetic field on growth and pubertal development in female Wistar rats. Electromagn Biol Med. 2015 Mar;34(1):63-71.
Show BibTeX
@article{o_2015_the_effects_of_longterm_2563,
  author = {Sangun O and Dundar B and Darici H and Comlekci S and Doguc DK and Celik S},
  title = {The effects of long-term exposure to a 2450 MHz electromagnetic field on growth and pubertal development in female Wistar rats.},
  year = {2015},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/24460416/},
}
PubMed: 24460416

Cited By (27 papers)

View all 27 citing papers on Semantic Scholar

Quick Questions About This Study

Prenatal and postnatal groups were exposed to EMF 1 h/day beginning from intrauterine and postnatal periods, respectively, while a third group was sham-exposed.
Prenatal exposure led to significantly lower daily mass gain and significantly later puberty.
Total oxidant status and oxidative stress index were significantly increased in brain and ovary tissues of the prenatal group compared to the control group.
Serum LH levels were increased in both prenatal and postnatal groups, while FSH and E2 levels did not differ among groups.
Histological examinations revealed no statistically significant differences between the groups.