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Melatonin attenuates radiofrequency radiation (900 MHz)- induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice

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Pandey N, Giri S · 2018

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Melatonin's antioxidative properties and ability to enhance DNA repair mechanisms appear to protect against radiofrequency radiation-induced reproductive damage in male mice.

Plain English Summary

Summary written for general audiences

This study examined the effects of 900 MHz radiofrequency radiation (RFR) exposure on male mouse germ cells and whether melatonin supplementation could mitigate these effects. The researchers found that RFR exposure caused DNA damage, oxidative stress, and disrupted spermatogenesis, but these harmful effects were significantly reduced or prevented in mice that received melatonin supplementation.

Why This Matters

This study uses an animal model to investigate potential mechanisms of RFR effects on male reproductive health, which is relevant given widespread mobile phone exposure. The use of both oxidative stress markers and comet assay for DNA damage provides multiple lines of evidence for the proposed mechanisms.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Pandey N, Giri S (2018). Melatonin attenuates radiofrequency radiation (900 MHz)- induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice.
Show BibTeX
@article{pandey_n_giri_s_ce2561,
  author = {Pandey N and Giri S},
  title = {Melatonin attenuates radiofrequency radiation (900 MHz)- induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice},
  year = {2018},
  doi = {10.1038/s41467-018-03851-3},
  
}
DOI: 10.1038/s41467-018-03851-3PubMed: 29562845

Quick Questions About This Study

Plants grow longer root hairs when phosphate is scarce, increasing surface area to search for this essential nutrient. This adaptive response is controlled by the hormone auxin and specific genes like ARF19, RSL2, and RSL4.
Auxin acts as a signaling molecule that coordinates cellular responses to environmental challenges. It must be synthesized by TAA1 enzymes and transported by AUX1 proteins to trigger appropriate adaptive changes in root hair growth.
Three key transcription factors, ARF19, RSL2, and RSL4, regulate root hair growth when phosphate levels are low. These auxin-inducible genes coordinate the cellular machinery needed for hair elongation and nutrient foraging.
No, plants with disrupted auxin transport (like aux1 mutants) cannot properly respond to phosphate deficiency. However, researchers showed this response can be rescued by targeting AUX1 expression to specific root cells.
Phosphate doesn't move easily through soil, so plants must actively search for it by growing longer root hairs. This immobility makes the auxin-controlled adaptive response essential for plant survival in phosphate-poor environments.