Melatonin attenuates radiofrequency radiation (900 MHz)-induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice
Pandey N, Giri S · 2018
Melatonin supplementation appeared to protect against radiofrequency radiation-induced reproductive damage in male mice by counteracting oxidative stress and supporting DNA repair processes.
Plain English Summary
This study examined the effects of 900 MHz radiofrequency radiation (RFR) exposure on male mouse germ cells and spermatogenesis, and whether melatonin supplementation could mitigate these effects. The researchers found that RFR exposure caused DNA damage, oxidative stress, cell cycle arrest, reduced sperm count, and sperm abnormalities, while melatonin supplementation prevented or reduced these adverse effects through antioxidant mechanisms and DNA repair pathway improvement.
Why This Matters
This animal study adds to existing research on potential biological effects of mobile phone radiofrequency exposure on male fertility. The protective effect of melatonin, an endogenous antioxidant, suggests oxidative stress as a potential mechanism of RFR-induced reproductive toxicity, though findings in animal models do not directly translate to human health outcomes.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{pandey_n_giri_s_ce3827,
author = {Pandey N and Giri S},
title = {Melatonin attenuates radiofrequency radiation (900 MHz)-induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice},
year = {2018},
doi = {10.1038/s41467-018-03851-3},
}