8,655 Studies Reviewed. 86.9% Found Biological Effects. The Evidence is Clear.
Shield Your Body
Immune System

Induced Neurodifferentiation of hBM- MSCs through Activation of the ERK/CREB Pathway via Pulsed Electromagnetic Fields and Physical Stimulation Promotes Neurogenesis in Cerebral Ischemic Models

Bioeffects Seen

Park H-J, Choi J-H, Nam M-H, Seo Y-K · 2022

Share:

Pulsed electromagnetic fields combined with physical stimulation may promote neurogenic potential in stem cells through specific molecular pathways relevant to ischemic brain injury models.

Plain English Summary

Summary written for general audiences

This 2022 review examined how pulsed electromagnetic fields and physical stimulation can induce neurodifferentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) through activation of the ERK/CREB signaling pathway. The study focused on how these mechanisms promote neurogenesis in models of cerebral ischemia.

Why This Matters

The ERK/CREB pathway is a well-characterized intracellular signaling cascade involved in cell differentiation and neuroprotection. Mesenchymal stem cell differentiation into neural lineages represents a potential therapeutic strategy for neurodegenerative and acute neurological conditions.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Park H-J, Choi J-H, Nam M-H, Seo Y-K (2022). Induced Neurodifferentiation of hBM- MSCs through Activation of the ERK/CREB Pathway via Pulsed Electromagnetic Fields and Physical Stimulation Promotes Neurogenesis in Cerebral Ischemic Models.
Show BibTeX
@article{park_h_j_choi_j_h_nam_m_h_seo_y_k_ce4173,
  author = {Park H-J and Choi J-H and Nam M-H and Seo Y-K},
  title = {Induced Neurodifferentiation of hBM- MSCs through Activation of the ERK/CREB Pathway via Pulsed Electromagnetic Fields and Physical Stimulation Promotes Neurogenesis in Cerebral Ischemic Models},
  year = {2022},
  
  
}

Quick Questions About This Study

Yes, lung and chest involvement occurs in 20-90% of SLE patients according to this review. The wide range reflects different types of lung complications, from mild pleural inflammation to life-threatening bleeding.
Diffuse alveolar hemorrhage (DAH) has the highest mortality rate at 68-75%. This condition involves bleeding into the lung's air sacs and requires immediate aggressive treatment with immunosuppressive drugs.
The study identified eight distinct types: lupus pleuritis, pleural effusion, acute pneumonitis, shrinking lung syndrome, interstitial lung disease, diffuse alveolar hemorrhage, pulmonary hypertension, and pulmonary embolism.
The exact mechanism isn't fully understood, but systemic type 1 interferons, circulating immune complexes, and neutrophils appear to play essential roles in triggering lung inflammation and damage.
Rituximab has been successfully used for three specific types: lupus pleuritis, acute lupus pneumonitis, and shrinking lung syndrome, though corticosteroids and cyclophosphamide remain standard treatments.