DNA damage in Molt-4 T- lymphoblastoid cells exposed to cellular telephone radiofrequency fields in vitro
Phillips, J.L., Ivaschuk, O., Ishida-Jones, T., Jones, R.A., Campbell-Beachler, M. and Haggren, W. · 1998
View Original AbstractExposure of Molt-4 T-lymphoblastoid cells to cellular telephone radiofrequency signals either increased or decreased DNA damage depending on the signal type and SAR level.
Plain English Summary
Researchers exposed Molt-4 T-lymphoblastoid cells in vitro to pulsed radiofrequency signals at cellular telephone frequencies of 813.5625 MHz (iDEN® signal) and 836.55 MHz (TDMA signal) to detect DNA damage. The alkaline comet assay was used to measure DNA single-strand breaks in exposed cell cultures compared to sham-exposed cultures. At an SAR of 24 μW g−1, exposure to the iDEN® signal for 2 h and 21 h significantly increased DNA damage, while at 2.4 μW g−1 the same signal significantly decreased DNA damage. The researchers concluded that the data indicate a need to study the effects of exposure to RF signals on direct DNA damage and on the rate at which DNA damage is repaired.
Why This Matters
These studies were designed to look for athermal RF effects. Tail moment and comet extent were calculated as indicators of DNA damage. Statistical differences between exposed and control cultures were evaluated with the Kolmogorov-Smirnoff distribution test. Exposure to the TDMA signal at an SAR of 2.6 μW g−1 for both 2 h and 21 h significantly decreased DNA damage, and at 26 μW g−1 for 2 h it also significantly decreased DNA damage. The direction of the effect differed by SAR level for the iDEN® signal, with decreased damage at the lower SAR and increased damage at the higher SAR.
Exposure Details
- SAR
- 0.0024 & 0.024 W/kg
- Source/Device
- 813.5625 MHz (iDEN® signal)
- Exposure Duration
- 2 h or 21 h
Where This Falls on the Concern Scale
Study Details
To detect DNA damage in Molt-4 T-lymphoblastoid cells exposed to cellular telephone radiofrequency fields in vitro.
Molt-4 T-lymphoblastoid cells have been exposed to pulsed signals at cellular telephone frequencies ...
It was found that: 1) exposure of cells to the iDEN® signal at an SAR of 2.4 μW g−1 for 2 h or 21 h ...
The data indicate a need to study the effects of exposure to RF signals on direct DNA damage and on the rate at which DNA damage is repaired.
Show BibTeX
@article{phillips_1998_dna_damage_in_molt4_49,
author = {Phillips and J.L. and Ivaschuk and O. and Ishida-Jones and T. and Jones and R.A. and Campbell-Beachler and M. and Haggren and W.},
title = {DNA damage in Molt-4 T- lymphoblastoid cells exposed to cellular telephone radiofrequency fields in vitro},
year = {1998},
url = {http://www.sciencedirect.com/science/article/pii/S0302459898000749},
}