Pre-exposure to 50 Hz magnetic fields modifies menadione-induced genotoxic effects in human SH-SY5Y neuroblastoma cells
Authors not listed · 2011
Pre-exposure to 50 Hz magnetic fields at 100 µT enhanced menadione-induced DNA damage, DNA repair rate, and micronucleus formation in human SH-SY5Y neuroblastoma cells.
Plain English Summary
Researchers exposed human SH-SY5Y neuroblastoma cells to 50 Hz magnetic fields at 100 µT for 24 hours followed by chemical exposure for 3 hours. The chemicals used were menadione and methyl methanesulphonate to induce DNA damage and micronucleus formation. Pre-treatment with magnetic fields enhanced menadione-induced DNA damage, DNA repair rate, and micronucleus formation. Similar effects were seen with methyl methanesulphonate but were not statistically significant. No effects were observed from magnetic field exposure alone.
Why This Matters
The authors concluded that pre-exposure to magnetic fields as low as 100 µT alters cellular responses to menadione and increases genotoxicity. They also suggested that complementary data at several chronological points may be critical for understanding magnetic field effects on DNA damage, repair, and post-repair genome integrity.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{pre_exposure_to_50_hz_magnetic_fields_modifies_menadione_induced_genotoxic_effects_in_human_sh_sy5y_neuroblastoma_cells_ce2119,
author = {Unknown},
title = {Pre-exposure to 50 Hz magnetic fields modifies menadione-induced genotoxic effects in human SH-SY5Y neuroblastoma cells},
year = {2011},
doi = {10.1371/journal.pone.0018021},
}