8,655 Studies Reviewed. 86.9% Found Biological Effects. The Evidence is Clear.

PRELIMINARY STUDY OF THE EFFECT OF ARTIFICIAL FEVER UPON HOPELESS TUMOR CASES

Bioeffects Seen

Stafford L. Warren · 1935

Share:

Early research showed artificially induced fever could treat hopeless cancer cases, establishing heat-based therapy principles still studied today.

Plain English Summary

Summary written for general audiences

This 1935 study by Warren investigated using artificially induced fever (hyperthermia) as a treatment for advanced cancer cases that were considered hopeless with conventional therapy. The research explored whether controlled elevation of body temperature could provide therapeutic benefits for malignant tumors.

Why This Matters

This pioneering 1935 research represents one of the earliest formal investigations into hyperthermia as a cancer treatment, establishing foundational principles that remain relevant to modern EMF health discussions. The science demonstrates that controlled heating of biological tissues can have profound effects on cellular function and tumor behavior. What this means for you is understanding that electromagnetic fields, which can generate heat in tissues through various mechanisms, may have therapeutic potential alongside their documented risks. The reality is that the same physical principles Warren explored in 1935 apply today when we consider how radiofrequency radiation from cell phones, WiFi, and other wireless devices deposits energy in our bodies. While Warren used external heating methods, modern EMF exposure creates localized heating patterns that researchers continue to study for both harmful and potentially beneficial effects.

Exposure Information

Specific exposure levels were not quantified in this study. Duration: Various durations including 12 hours at 41.5°C for mouse sarcoma No. 180, 5 hours less at 42°C, 15 hours at 42°C for Brown-Pearce rabbit epithelioma, 7 hours of local exposure, 13 hours of fever treatment, 21 hours of fever treatment, and 5 hours of fever treatment

Study Details

To study the effect of artificial fever upon hopeless tumor cases, including in vitro and in vivo effects on animal tumors, temperature gradients during heating, and therapeutic effects in human cases with widespread metastases

Animal tumor studies included in vitro exposure of tumor tissue slices to temperatures of 41.5 and 4...

In vitro studies showed definite lethal time-temperature relationships for transplantable animal tum...

There is experimental evidence suggesting a definite 'thermal death time' for transplantable animal tumors at high febrile temperatures. Heat distribution by circulating blood allows internal organs and tumors to reach and maintain predetermined temperature levels. Artificial fever therapy showed some destructive effect on tumor cells in human cases, though no cures were achieved. Further research is warranted to determine if this approach can provide additional aid in treating malignant disease.

Cite This Study
Stafford L. Warren (1935). PRELIMINARY STUDY OF THE EFFECT OF ARTIFICIAL FEVER UPON HOPELESS TUMOR CASES.
Show BibTeX
@article{preliminary_study_of_the_effect_of_artificial_fever_upon_hopeless_tumor_cases_g5576,
  author = {Stafford L. Warren},
  title = {PRELIMINARY STUDY OF THE EFFECT OF ARTIFICIAL FEVER UPON HOPELESS TUMOR CASES},
  year = {1935},
  
  
}
No DOI on file for this study.

Quick Questions About This Study

Artificial fever therapy involved deliberately raising patients' body temperatures to create controlled hyperthermia conditions. Researchers like Warren believed elevated temperatures could help destroy cancer cells or boost the body's natural immune response against tumors.
In 1935, conventional cancer treatments were extremely limited, leaving many cases truly hopeless. Researchers observed that some cancer patients improved after natural fevers, leading them to investigate whether artificially induced hyperthermia could replicate these beneficial effects.
Warren's work established that controlled tissue heating affects cellular function and tumor behavior. Today's EMF research builds on these same thermal principles, studying how electromagnetic fields deposit energy and create heating patterns in human tissues.
This study was among the first formal investigations into hyperthermia as cancer therapy, establishing scientific foundations for heat-based treatments. It helped legitimize research into how temperature changes affect malignant cells, influencing decades of subsequent therapeutic development.
Modern hyperthermia cancer treatments evolved from Warren's early work, now using sophisticated electromagnetic heating systems. Today's approaches combine controlled heating with chemotherapy or radiation, achieving better precision and safety than 1935 methods allowed.