Prophylactic Effects of Radiofrequency Electromagnetic Field on Pulmonary Ischemia-Reperfusion via HIF-1α/eNOS Pathway and BCL2/BAX Signaling
Authors not listed · 2025
RF-EMF treatment improved all measured parameters in a rat lung ischemia-reperfusion model, showing antioxidant, antiapoptotic, and anti-inflammatory effects via the HIF-1α/eNOS and BCL-2/BAX pathways.
Plain English Summary
Forty male Wistar rats were randomly divided into four groups (Sham, IR, IR+RF-EMF, RF-EMF), and IR was applied by 60 minutes of left lung hilus clamping followed by 60 minutes of reperfusion, while all rats were kept in the RF-EMF unit for 60 minutes with or without activation. IR injury increased emphysematous findings, hyperemia, septal thickness, TNF-alpha and caspase-3 expression, and raised total oxidant status, oxidative stress index, HIF-1α, eNOS, and BAX while decreasing BCL2. In the IR+RF-EMF group, improvement was detected in all parameters, indicating antioxidant, antiapoptotic, and anti-inflammatory effects through the HIF-1α/eNOS and BCL-2/BAX pathways.
Why This Matters
Lung tissues were collected for histopathological, immunohistochemical, biochemical, and genetic analyses. The authors state that the use of RF-EMF in IR damage is promising, as models that examine the long-term effects of RF-EMF at different frequencies.
Show BibTeX
@article{prophylactic_effects_of_radiofrequency_electromagnetic_field_on_pulmonary_ischemia_reperfusion_via_hif_1enos_pathway_and_bcl2bax_signaling_ce2286,
author = {Unknown},
title = {Prophylactic Effects of Radiofrequency Electromagnetic Field on Pulmonary Ischemia-Reperfusion via HIF-1α/eNOS Pathway and BCL2/BAX Signaling},
year = {2025},
doi = {10.1002/pul2.70051},
}