Pulsed electromagnetic fields mediate sensory nerve regulation for bone formation in aging models
Authors not listed · 2025
PEMFs enhance new bone formation and innervation in aging male mice by stimulating sensory nerves to secrete Sema3A, and the Sema3A-Nrp1 pathway is central for anti-senescence effects on MSCs.
Plain English Summary
The study found that PEMFs increased new bone formation and nerve innervation, promoting osteogenesis and reducing adipogenesis in MSCs of aging male mice. PEMF-induced osteogenesis was impaired when sensory nerves were dysfunctional. PEMFs stimulated sensory nerves to secrete Sema3A, which acted through the Nrp1 receptor on leptin-receptor-expressing MSCs to drive osteogenesis, inhibit adipogenesis, and counteract cellular senescence. Depleting sensory nerves or knocking out Sema3A or Nrp1 abolished the bone-forming effects of PEMFs.
Why This Matters
The researchers noted that while PEMFs are known to enhance bone formation against osteoporosis, how they support bone health during aging was not understood. The authors concluded that the findings highlight the therapeutic potential of PEMFs for osteoporosis in aging males.
Show BibTeX
@article{pulsed_electromagnetic_fields_mediate_sensory_nerve_regulation_for_bone_formation_in_aging_models_ce4254,
author = {Unknown},
title = {Pulsed electromagnetic fields mediate sensory nerve regulation for bone formation in aging models},
year = {2025},
}