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Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study

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Liao F, Li Y, Zhang Z, Yu Q, Liu H · 2025

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PEMFs induce metabolic reprogramming in fibroblasts toward glycolytic energy generation accompanied by increased vesicular transport, which may support wound healing processes in vitro.

Plain English Summary

Summary written for general audiences

This in vitro study investigated how pulsed electromagnetic fields (PEMFs) at 4mT and 80 Hz affect energy metabolism during wound healing using L929 fibroblast cells. The researchers found that PEMF exposure promoted cell migration and viability while shifting energy production from mitochondrial respiration to glycolysis, and enhanced vesicular transport toward the nucleus.

Why This Matters

Wound healing is a metabolically intensive process requiring coordinated cellular responses. Metabolic reprogramming toward glycolysis has been observed in other cellular contexts requiring rapid energy mobilization and biosynthesis, suggesting a plausible mechanism for PEMF-enhanced wound healing support.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Liao F, Li Y, Zhang Z, Yu Q, Liu H (2025). Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study.
Show BibTeX
@article{pulsed_electromagnetic_fields_modulate_energy_metabolism_during_wound_healing_process_an_in_vitro_model_study_ce4106,
  author = {Liao F and Li Y and Zhang Z and Yu Q and Liu H},
  title = {Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study},
  year = {2025},
  doi = {10.3760/cma.j.cn112141-20250529-00244},
  
}
DOI: 10.3760/cma.j.cn112141-20250529-00244PubMed: 39939866

Quick Questions About This Study

No, despite the title mentioning electromagnetic fields, the abstract describes Chinese medical consensus guidelines for hormone treatments in gynecology, with no EMF research content.
Nothing in this case. The study abstract focuses entirely on pharmaceutical hormone treatments for conditions like endometriosis and fertility procedures, not electromagnetic field exposure.
This appears to be a database classification error where the title mentioning 'pulsed electromagnetic fields' doesn't match the actual study content about medical hormone protocols.
No, the document provides clinical guidelines for gynecologists using hormone therapies, covering dosing, safety monitoring, and treatment protocols for reproductive health conditions.
No, since this study doesn't actually research electromagnetic fields or their biological effects, it provides no relevant information for EMF health or safety considerations.