Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study
Authors not listed · 2025
PEMFs at 4 mT and 80 Hz promoted L929 cell migration and viability, made the cells highly glycolytic, and increased vesicle generation and transport toward the nucleus.
Plain English Summary
The researchers used scratch-wound healing and cell viability assays to test how PEMFs affect L929 fibroblast migration and survival. Exposure to PEMFs at 4 mT and 80 Hz increased cell migration and viability. Seahorse glycolysis and mitochondrial stress tests showed that exposed cells became highly glycolytic, while intracellular acidification rose and ROS levels stayed low. More vesicles were generated and transported toward the nucleus in PEMF-treated L929 cells. The authors concluded that PEMFs reprogram fibroblast metabolism from mitochondrial respiration to glycolysis and boost vesicular transport, linking these changes to wound healing.
Why This Matters
The study notes that PEMF therapy has been widely explored for wound healing, a process that demands high metabolism. The authors state that the impact of PEMFs on energy metabolism in wound healing has remained largely unexplored. They therefore aimed to demonstrate the role of PEMFs on energy metabolism in wound healing.
Show BibTeX
@article{pulsed_electromagnetic_fields_modulate_energy_metabolism_during_wound_healing_process_an_in_vitro_model_study_ce4106,
author = {Unknown},
title = {Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study},
year = {2025},
}