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Microarray profiling of LncRNA expression in the testis of pubertal mice following morning and evening exposure to 1800 MHz radiofrequency fields

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Qin F, Cao H, Feng C, Zhu T, Zhu B, Zhang J, Tong J, Pei H · 2021

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1800 MHz radiofrequency exposure during puberty induced testicular toxicity and altered lncRNA expression patterns that differed significantly between morning and evening exposure times, involving pathways related to DNA damage, cell cycle, and spermatogenesis.

Plain English Summary

Summary written for general audiences

This study exposed four-week-old mice to 1800 MHz radiofrequency fields for three weeks during morning and evening periods to investigate effects on testicular development. The exposure resulted in decreased testicular weight, sperm production, and testosterone levels, along with dysregulation of long non-coding RNA expression, with morning exposure affecting 615 lncRNAs compared to 183 for evening exposure.

Why This Matters

The study uses microarray analysis and bioinformatic pathway analysis to investigate potential molecular mechanisms of RF-induced testicular effects in a pubertal mouse model. The finding of chronotoxicity (time-dependent effects) with differential lncRNA dysregulation between morning and evening exposures suggests circadian factors may modulate RF susceptibility.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Qin F, Cao H, Feng C, Zhu T, Zhu B, Zhang J, Tong J, Pei H (2021). Microarray profiling of LncRNA expression in the testis of pubertal mice following morning and evening exposure to 1800 MHz radiofrequency fields.
Show BibTeX
@article{qin_f_cao_h_feng_c_zhu_t_zhu_b_zhang_j_tong_j_pei_h_ce2977,
  author = {Qin F and Cao H and Feng C and Zhu T and Zhu B and Zhang J and Tong J and Pei H},
  title = {Microarray profiling of LncRNA expression in the testis of pubertal mice following morning and evening exposure to 1800 MHz radiofrequency fields},
  year = {2021},
  doi = {10.1016/j.cell.2021.08.023},
  
}
DOI: 10.1016/j.cell.2021.08.023PubMed: 34369206

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