Studying gene expression profile of rat neuron exposed to 1800MHz radiofrequency electromagnetic fields with cDNA microassay.
Zhao R, Zhang S, Xu Z, Ju L, Lu D, Yao G. · 2007
View Original AbstractExposure to 1800 MHz radiofrequency electromagnetic fields altered gene expression in rat neurons, with 24 genes up-regulated and 10 down-regulated.
Plain English Summary
Researchers investigated whether 1800 MHz radiofrequency electromagnetic fields could influence gene expression in rat neurons. Among 1200 candidate genes, 24 were up-regulated and 10 were down-regulated after 24 hours of intermittent exposure at a SAR of 2 W/kg. The researchers concluded that gene expression in rat neurons could be altered by exposure to radiofrequency electromagnetic fields under their experimental conditions.
Why This Matters
The study used an Affymetrix Rat Neurobiology U34 array to look at changes in gene expression in rat neurons. The radiofrequency signal was pulsed at 1800 MHz and modulated by 217 Hz. The altered genes were associated with multiple cellular functions, including cytoskeleton, signal transduction pathways, and metabolism. The microarray findings were further confirmed using quantitative real-time polymerase chain reaction.
Exposure Details
- SAR
- 2 W/kg
- Source/Device
- 1800 MHz modulated by 217 Hz
- Exposure Duration
- 24h
Exposure Context
This study used 2 W/kg for SAR (device absorption):
- 5x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The aim of this investigation was to determine whether 1800 MHz radiofrequency electromagnetic fields (RF EMF) can influence the gene expression of neuron.
Affymetrix Rat Neurobiology U34 array was applied to investigate the changes of gene expression in r...
Among 1200 candidate genes, 24 up-regulted genes and 10 down-regulated genes were identified after 2...
The present results indicated that the gene expression of rat neuron could be altered by exposure to RF EMF under our experimental conditions.
Show BibTeX
@article{r_2007_studying_gene_expression_profile_25,
author = {Zhao R and Zhang S and Xu Z and Ju L and Lu D and Yao G.},
title = {Studying gene expression profile of rat neuron exposed to 1800MHz radiofrequency electromagnetic fields with cDNA microassay.},
year = {2007},
url = {http://www.sciencedirect.com/science/article/pii/S0300483X07001837},
}