6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.
Shield Your Body

Note: This study found no significant biological effects under its experimental conditions. We include all studies for scientific completeness.

Cardiovascular

Analysis of proteome response to the mobile phone radiation in two types of human primary endothelial cells

No Effects Found

Nylund R, Kuster N, Leszczynski D · 2010

View Original Abstract
Share:

Exposure to 1800 MHz GSM radiation for one hour at 2.0 W/kg did not cause statistically significant changes in protein expression in two types of primary human endothelial cells.

Plain English Summary

Summary written for general audiences

Researchers exposed primary human umbilical vein endothelial cells and primary human brain microvascular endothelial cells to 1800 MHz GSM radiation for one hour at an average specific absorption rate of 2.0 W/kg. Protein expression patterns were examined immediately after exposure using two dimensional difference gel electrophoresis-based proteomics (2DE-DIGE). Exposure did not cause any statistically significant changes in protein expression in either cell type.

Why This Matters

The researchers examined whether 1800 MHz GSM radiation affects the proteome of primary human endothelial cells. The two cell types showed numerous proteome differences under sham conditions, likely reflecting physiological differences between vascular beds. The analysis applied a false discovery rate correction and examined proteomes immediately after exposure, finding no effect on protein expression.

Exposure Details

SAR
2 W/kg
Source/Device
1800 MHz GSM mobile phone

Exposure Context

This study used 2 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 2 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

In the present study, using as model human primary endothelial cells, we have examined whether exposure to 1800 MHz GSM mobile phone radiation can affect cell proteome.

Primary human umbilical vein endothelial cells and primary human brain microvascular endothelial cel...

Exposure of primary human endothelial cells to the mobile phone radiation, 1800 MHz GSM signal for 1 hour at an average specific absorption rate of 2.0 W/kg, does not affect protein expression, when the proteomes were examined immediately after the end of the exposure and when the false discovery rate correction was applied to analysis. This observation agrees with our earlier study showing that the 1800 MHz GSM radiation exposure had only very limited effect on the proteome of human endothelial cell line EA.hy926, as compared with the effect of 900 MHz GSM radiation.

Cite This Study
Nylund R, Kuster N, Leszczynski D (2010). Analysis of proteome response to the mobile phone radiation in two types of human primary endothelial cells Proteome Sci. 8:52, 2010.
Show BibTeX
@article{r_2010_analysis_of_proteome_response_2788,
  author = {Nylund R and Kuster N and Leszczynski D},
  title = {Analysis of proteome response to the mobile phone radiation in two types of human primary endothelial cells},
  year = {2010},
  doi = {10.1186/1477-5956-8-52},
  url = {https://proteomesci.biomedcentral.com/articles/10.1186/1477-5956-8-52},
}
DOI: 10.1186/1477-5956-8-52

Cited By (31 papers)

Quick Questions About This Study

Primary human umbilical vein endothelial cells and primary human brain microvascular endothelial cells were studied.
Cells were exposed to 1800 MHz GSM mobile phone radiation for 1 hour at an average specific absorption rate of 2.0 W/kg.
Protein expression patterns were examined using two dimensional difference gel electrophoresis-based proteomics (2DE-DIGE).
Exposure did not cause any statistically significant changes in protein expression in either cell type.
Numerous proteome differences were observed between the two cell types under sham conditions, likely reflecting physiological differences between vascular beds.