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DNA & Genetic Damage

Measurement of DNA damage in mammalian cells exposed in vitro to radiofrequency fields at sars of 3-5 w/kg.

No Effects Found

Li L, Bisht KS, LaGroye I, Zhang P, Straube WL, Moros EG, Roti Roti JL. · 2001

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Exposure of murine C3H 10T(1/2) cells to CDMA or FDMA at SAR up to 5.1 W/kg did not induce measurable DNA damage.

Plain English Summary

Summary written for general audiences

Researchers exposed murine C3H 10T(1/2) fibroblasts to radiofrequency fields at specific absorption rates of 3.2 to 5.1 W/kg. Cell cultures were exposed to 847.74 MHz CDMA and 835.62 MHz FDMA modulated radiations in radial transmission line irradiators with temperature regulated to 37.0 ± 0.3 °C. Using the alkaline comet assay, they found no statistically significant differences in comet moment or comet length between sham-exposed and exposed cells after 2, 4, or 24 hours of exposure, for both exponentially growing and plateau-phase cells. A 4-hour incubation after a 2-hour exposure also resulted in no significant changes in comet moment or comet length. The authors concluded that exposure at 37°C up to 5.1 W/kg did not induce measurable DNA damage.

Exposure Details

SAR
3.2 - 5.1 W/kg
Source/Device
847.74 MHz (CDMA) and 835.62 (FDMA)
Exposure Duration
2, 4 or 24 h

Exposure Context

This study used 3.2 - 5.1 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 3.2 - 5.1 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 2 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 847.7 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 847.7 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

In the present study, we determined whether exposure of mammalian cells to 3.2-5.1 W/kg specific absorption rate (SAR) radiofrequency fields could induce DNA damage in murine C3H 10T(1/2) fibroblasts.

Cell cultures were exposed to 847.74 MHz code-division multiple access (CDMA) and 835.62 frequency-d...

Using the alkaline comet assay to measure DNA damage, we found no statistically significant differen...

Our results show that exposure of cultured C3H 10T(1/2) cells at 37 degrees C CDMA or FDMA at SAR values of up to 5.1 W/kg did not induce measurable DNA damage.

Cite This Study
Li L, Bisht KS, LaGroye I, Zhang P, Straube WL, Moros EG, Roti Roti JL. (2001). Measurement of DNA damage in mammalian cells exposed in vitro to radiofrequency fields at sars of 3-5 w/kg. Radiat Res 156:328-332, 2001.
Show BibTeX
@article{l_2001_measurement_of_dna_damage_2918,
  author = {Li L and Bisht KS and LaGroye I and Zhang P and Straube WL and Moros EG and Roti Roti JL.},
  title = {Measurement of DNA damage in mammalian cells exposed in vitro to radiofrequency fields at sars of 3-5 w/kg.},
  year = {2001},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/11500143/},
}
PubMed: 11500143

Cited By (61 papers)

View all 61 citing papers on Semantic Scholar

Quick Questions About This Study

The study used murine C3H 10T(1/2) fibroblasts.
Cell cultures were exposed to 847.74 MHz CDMA and 835.62 MHz FDMA modulated radiations.
The SAR values ranged from 3.2 to 5.1 W/kg.
No statistically significant differences in comet moment or comet length were found between sham-exposed and exposed cells. The authors concluded that exposure up to 5.1 W/kg did not induce measurable DNA damage.