Radiofrequency electromagnetic field ınhibits HIF-1 alpha and activates eNOS signaling to prevent intestinal damage in a model of mesenteric artery ischemia in rats
Authors not listed · 2025
RF-EMF treatment reversed the MIR-induced molecular and pathological changes, with therapeutic treatment showing more effective recovery.
Plain English Summary
Researchers used 32 Wistar Albino rats divided into four groups: sham, MIR, prophylactic RF-EMF plus MIR, and therapeutic RF-EMF plus MIR. After the experiment, blood and terminal ileum samples were collected for histopathological, immunohistochemical, genetic, and biochemical analyses. In the MIR group, expressions of Cas-3, TNF-α, VEGF, BAX, and HIF-1α increased, while OSI levels and PCNA, BCL2, and eNOS expressions decreased. Marked hyperemia, hemorrhage, edema, inflammatory cell infiltrations, and erosion or ulcers were observed in the MIR group. Both prophylactic and therapeutic RF-EMF treatment reversed these molecular and pathological changes, with therapeutic treatment showing more effective recovery.
Why This Matters
The researchers noted that mesenteric artery ischemia and reperfusion can cause organ dysfunction through hypoxic damage mechanisms. They also stated that RF-EMF can enhance tissue vascularization via eNOS-mediated nitric oxide release. The study aimed to investigate the protective effect and mechanism of RF-EMF in ischemic intestinal injury in the MIR model. The authors concluded that RF-EMF treatment preserved tissue vascularization and reduced hypoxia-induced oxidative stress, inflammation, and apoptosis.
Show BibTeX
@article{radiofrequency_electromagnetic_field_nhibits_hif_1_alpha_and_activates_enos_signaling_to_prevent_intestinal_damage_in_a_model_of_mesenteric_artery_ischemia_in_rats_ce2549,
author = {Unknown},
title = {Radiofrequency electromagnetic field ınhibits HIF-1 alpha and activates eNOS signaling to prevent intestinal damage in a model of mesenteric artery ischemia in rats},
year = {2025},
doi = {10.7150/ijms.105479},
}