Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures
Authors not listed · 2021
Repeated electromagnetic field stimulation at 64 MHz reduced amyloid-β peptide levels in primary human brain cultures.
Plain English Summary
Researchers exposed primary human brain cultures at day 7 to 64 MHz electromagnetic fields for one hour daily over 14 days. This treatment significantly lowered secreted Aβ40 and Aβ42 peptide levels compared to untreated cultures. Similar reductions were also observed with one or two hours of daily exposure over 14 days, and with 4 or 8 days of exposure in cultures at a later stage. The minimum specific absorption rate needed for a biological effect was 0.4 W/kg. Exposure did not cause cellular toxicity or change sAPPα levels, indicating the Aβ reduction was not due to a shift to the α-secretase pathway.
Why This Matters
The electromagnetic field frequency and power used in the study are the same as those used in human magnetic resonance imaging. The researchers suggest that repeated electromagnetic field stimulation could be further developed for clinical use to modulate amyloid-β deposition.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{repeated_electromagnetic_field_stimulation_lowers_amyloid_peptide_levels_in_primary_human_mixed_brain_tissue_cultures_ce3442,
author = {Unknown},
title = {Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures},
year = {2021},
doi = {10.1038/s41598-020-77808-2},
}