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Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice

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Authors not listed · 2025

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5G frequencies trigger subtle brain gene changes without behavioral effects, raising questions about long-term cellular impacts.

Plain English Summary

Summary written for general audiences

Researchers exposed mice to 5G signals at 3.5 GHz frequency for six weeks, finding no changes in behavior or memory but detecting subtle gene expression changes in brain tissue. The study found less than 1% of brain genes were affected, with changes concentrated in areas handling nerve communication and cellular energy production.

Why This Matters

This study provides important insights into 5G's biological effects at the cellular level. While the researchers found no behavioral changes, the detection of gene expression alterations in brain tissue raises questions about long-term consequences of repeated 5G exposure. The fact that genes related to glutamatergic synapses and mitochondrial function were affected suggests these frequencies can influence fundamental cellular processes, even at relatively low power levels averaging 0.19 W/kg. What's particularly noteworthy is the asymmetrical response between brain hemispheres, with the more heavily exposed right cortex showing distinct mitochondrial gene changes. This demonstrates that even when behavioral effects aren't immediately apparent, biological responses are occurring at the molecular level.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 3.5 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 3.5 GHzPower lines50/60 HzCell phones~1 GHz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study.

Cite This Study
Unknown (2025). Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice.
Show BibTeX
@article{repeated_head_exposures_to_a_5g_35_ghz_signal_do_not_alter_behavior_but_modify_intracortical_gene_expression_in_adult_male_mice_ce2891,
  author = {Unknown},
  title = {Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice},
  year = {2025},
  doi = {10.3390/ijms26062459},
  
}

Quick Questions About This Study

No, the study found no significant changes in locomotion, exploration, anxiety levels, or memory processes after six weeks of daily 5G exposure in mice.
Less than 1% of brain genes showed changes, primarily those related to glutamatergic synapses (nerve communication) and mitochondrial genome functions (cellular energy production).
Mice received 1 hour of 5G exposure daily, 5 days per week for six weeks, at an average brain absorption rate of 0.19 W/kg.
No, the right cortex (higher exposure at 0.43 W/kg) showed different gene responses than the left cortex (0.14 W/kg), particularly in mitochondrial genes.
Yes, this study demonstrates that 5G exposure can alter brain gene expression at the cellular level without producing detectable changes in behavior or cognitive function.