Hyperactivity caused by a nitric oxide synthase inhibitor is countered by ultra-wideband pulses.
Seaman RL, Belt ML, Doyle JM, Mathur SP · 1999
View Original AbstractUltra-wideband electromagnetic pulses at 102,000 V/m eliminated drug-induced hyperactivity in mice, demonstrating direct EMF influence on brain chemistry.
Plain English Summary
Researchers exposed mice to ultra-wideband electromagnetic pulses at extremely high field strength (102,000 volts per meter) to see if it could counteract the hyperactive behavior caused by blocking nitric oxide production in the brain. The electromagnetic exposure successfully eliminated the drug-induced hyperactivity, suggesting the pulses somehow restored normal nitric oxide function. This demonstrates that pulsed electromagnetic fields can directly influence brain chemistry and behavior in laboratory animals.
Why This Matters
This study reveals something significant about how electromagnetic fields interact with our neurochemistry. The researchers used field strengths of 102,000 volts per meter - that's roughly 100 times stronger than what you'd experience standing directly under high-voltage power lines. While these exposure levels are far beyond everyday experience, the biological mechanism is what matters here. The study suggests that pulsed electromagnetic fields can influence nitric oxide production, a critical signaling molecule in the brain that affects everything from blood flow to neurotransmitter function. What makes this particularly relevant is that nitric oxide disruption has been linked to various neurological conditions, and this research shows EMF can modulate this system. The reality is that if laboratory-controlled electromagnetic pulses can alter brain chemistry enough to change behavior, we need to better understand how the lower-level but chronic exposures from our wireless devices might be affecting our neurological function over time.
Exposure Details
- Electric Field
- 102000 V/m
- Exposure Duration
- 30 min
Exposure Context
This study used 102000 V/m for electric fields:
- 340Kx above the Building Biology guideline of 0.3 V/m
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Study Details
Potential action of ultra-wideband (UWB) electromagnetic field pulses on effects of N(G)-nitro- L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), on nociception and locomotor activity was investigated in CF-1 mice.
Animals were injected IP with saline or 50 mg/kg L-NAME and exposed for 30 min to no pulses (sham ex...
Exposure to UWB pulses reduced the L-NAME-induced increase in back-paw-lick latency by 22%, but thi...
Show BibTeX
@article{rl_1999_hyperactivity_caused_by_a_1316,
author = {Seaman RL and Belt ML and Doyle JM and Mathur SP},
title = {Hyperactivity caused by a nitric oxide synthase inhibitor is countered by ultra-wideband pulses.},
year = {1999},
url = {https://pubmed.ncbi.nlm.nih.gov/10495308/},
}