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Sinusoidal ELF magnetic fields affect acetylcholinesterase activity in cerebellum synaptosomal membranes.

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Ravera S, Bianco B, Cugnoli C, Panfoli I, Calzia D, Morelli A, Pepe IM. · 2010

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Power-frequency magnetic fields at 0.74 mT reduced brain enzyme activity by 27%, disrupting the cleanup of crucial neurotransmitters.

Plain English Summary

Summary written for general audiences

Researchers exposed brain tissue to 50 Hz magnetic fields (power line frequency) and found it reduced activity of a key brain enzyme by 27%. This enzyme controls nerve communication for memory and learning, suggesting power-frequency fields can disrupt basic brain chemistry.

Why This Matters

This study provides direct evidence that power-frequency magnetic fields can disrupt brain biochemistry at the cellular level. The researchers found that exposure to 50 Hz magnetic fields at 0.74 mT reduced acetylcholinesterase activity by 27%. Put simply, this enzyme is responsible for clearing acetylcholine from nerve synapses after it delivers its message. When this cleanup process is impaired, acetylcholine accumulates, potentially disrupting normal brain function.

What makes this research particularly significant is the exposure level tested. At 0.74 mT (740 milligauss), this is well within the range of magnetic fields you might encounter near power lines, electrical panels, or some household appliances. The science demonstrates that even brief exposures at these levels can measurably alter brain enzyme function. While the effects were reversible in this laboratory study, the implications for chronic exposure in real-world settings deserve serious consideration, especially given acetylcholine's critical role in memory, learning, and neurological development.

Exposure Details

Magnetic Field
0.74 mG
Source/Device
50 Hz

Exposure Context

This study used 0.74 mG for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 0.74 mGExtreme Concern5 mGFCC Limit2,000 mGEffects observed in the Slight Concern range (Building Biology)FCC limit is 2,703x higher than this exposure level

Study Details

The aim of this study is to observe Sinusoidal ELF magnetic fields affect acetylcholinesterase activity in cerebellum synaptosomal membranes.

The effects of extremely low frequency magnetic fields (ELF-MF) on acetylcholinesterase (AChE) activ...

Sinusoidal fields with 50 Hz frequency and different amplitudes caused AChE activity to decrease abo...

The results are discussed in order to give an interpretation at molecular level of the macroscopic effects produced by ELF-MF on biological systems, in particular the alterations of embryo development in many organisms due to acetylcholine accumulation.

Cite This Study
Ravera S, Bianco B, Cugnoli C, Panfoli I, Calzia D, Morelli A, Pepe IM. (2010). Sinusoidal ELF magnetic fields affect acetylcholinesterase activity in cerebellum synaptosomal membranes. Bioelectromagnetics. 31(4):270-276, 2010.
Show BibTeX
@article{s_2010_sinusoidal_elf_magnetic_fields_698,
  author = {Ravera S and Bianco B and Cugnoli C and Panfoli I and Calzia D and Morelli A and Pepe IM.},
  title = {Sinusoidal ELF magnetic fields affect acetylcholinesterase activity in cerebellum synaptosomal membranes.},
  year = {2010},
  doi = {10.1002/bem.20563},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.20563},
}

Quick Questions About This Study

Researchers exposed brain tissue to 50 Hz magnetic fields (power line frequency) and found it reduced activity of a key brain enzyme by 27%. This enzyme controls nerve communication for memory and learning, suggesting power-frequency fields can disrupt basic brain chemistry.