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Cytotoxic and genotoxic effects of high-frequency electromagnetic fields (GSM 1800 MHz) on immature and mature rats

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Sekeroğlu V, Akar A, Sekeroğlu ZA · 2012

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Exposure to 1800 MHz EMF produced significant cytogenotoxic damage in bone marrow cells of immature and mature rats, with greater and irreversible effects in immature rats.

Plain English Summary

Summary written for general audiences

Researchers investigated the cytogenotoxic effects of 1800 MHz electromagnetic fields on bone marrow cells of immature and mature rats over 45 days with a 15-day recovery period. Significant differences were observed in chromosome aberrations, micronucleus frequency, mitotic index, and polychromatic erythrocyte ratio in all treatment groups. A 15-day recovery period did not improve the cytogenotoxic damage in immature rats.

Why This Matters

The study included two control groups for both immature and mature rats. The authors concluded that further studies are needed to understand EMF effects on DNA damage and repair and to determine safe limits, especially for children.

Exposure Details

SAR
0.37 , 0.49 W/kg
Source/Device
GSM 1800 MHz
Exposure Duration
2h/day for 45 day

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.37 , 0.49 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 4 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

We investigated the cytogenotoxic effects of high frequency electromagnetic fields (HF-EMF) for 45 day and the effect of a recovery period of 15 day after exposure to EMF on bone marrow cells of immature and mature rats.

The animals in treatment groups were exposed to 1800 MHz EMF at SAR of 0.37 W/kg and 0.49 W/kg for 2...

Significant differences were also observed in chromosome aberrations (CA), micronucleus (MN) freque...

Cite This Study
Sekeroğlu V, Akar A, Sekeroğlu ZA (2012). Cytotoxic and genotoxic effects of high-frequency electromagnetic fields (GSM 1800 MHz) on immature and mature rats Ecotoxicol Environ Saf. 80:140-144, 2012.
Show BibTeX
@article{v_2012_cytotoxic_and_genotoxic_effects_1319,
  author = {Sekeroğlu V and Akar A and Sekeroğlu ZA},
  title = {Cytotoxic and genotoxic effects of high-frequency electromagnetic fields (GSM 1800 MHz) on immature and mature rats},
  year = {2012},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/22405939/},
}
PubMed: 22405939

Cited By (28 papers)

Quick Questions About This Study

Rats were exposed to 1800 MHz EMF at SAR values of 0.37 W/kg and 0.49 W/kg for 2 hours per day over 45 days.
Chromosome aberrations, micronucleus frequency, mitotic index, and polychromatic erythrocyte ratio were measured.
Cytogenotoxic damage was more remarkable in immature rats than in mature rats.
The recovery period did not improve the cytogenotoxic damage in immature rats.
Further studies are needed to understand EMF effects on DNA damage and repair and to determine safe limits, especially for children.