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DNA & Genetic Damage

2- GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells

No Effects Found

Sekijima M, Takeda H, Yasunaga K, Sakuma N, Hirose H, Nojima T, Miyakoshi J. 2- GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells · 2010

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96-hour exposure to 3G cell phone frequencies showed no cellular damage in laboratory conditions.

Plain English Summary

Summary written for general audiences

Japanese researchers exposed human brain and lung cells to 2.1 GHz radiofrequency radiation (similar to 3G cell phone signals) for up to 96 hours at various power levels. They found no significant effects on cell growth, survival, or gene expression patterns. The study suggests that RF exposure within international safety guidelines doesn't trigger cellular stress responses in laboratory conditions.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.1425 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.1425 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale
Cite This Study
Sekijima M, Takeda H, Yasunaga K, Sakuma N, Hirose H, Nojima T, Miyakoshi J. 2- GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells (2010). 2- GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells.
Show BibTeX
@article{sekijima_m_takeda_h_yasunaga_k_sakuma_n_hirose_h_nojima_t_miyakoshi_j_2_ghz_band_cw_and_w_cdma_modulated_radiofrequency_fields_have_no_significant_effect_on_cell_proliferation_and_gene_expression_prof_ce3017,
  author = {Sekijima M and Takeda H and Yasunaga K and Sakuma N and Hirose H and Nojima T and Miyakoshi J. 2- GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells},
  title = {2- GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells},
  year = {2010},
  doi = {10.1269/JRR.09126},
  
}
DOI: 10.1269/JRR.09126PubMed: 20215713

Quick Questions About This Study

No significant effects on cell proliferation or viability were observed in human brain and lung cells exposed to 2.1 GHz W-CDMA radiation for up to 96 hours, even at high SAR levels of 800 mW/kg.
Less than 1% of genes showed altered expression in human cells exposed to 2.1 GHz radiation. This minimal change was not considered biologically significant and fell within normal cellular variation ranges.
Researchers tested three specific absorption rates: 80, 250, and 800 mW/kg. The highest level (800 mW/kg) approaches but remains below typical cell phone SAR limits of 1.6-2.0 W/kg.
No differences were found between continuous wave (CW) and W-CDMA modulated signals at 2.1 GHz. Both signal types produced essentially identical results across all tested parameters in human cells.
Three human cell lines were studied: A172 glioblastoma (brain cancer cells), H4 neuroglioma (brain tumor cells), and IMR-90 fibroblasts (normal fetal lung cells). All showed similar resistance to RF effects.