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Shahin S, Singh SP, Chaturvedi CM 2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax-caspase-3 mediated pathway

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Authors not listed · 2018

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2.45 GHz microwave radiation exposure induced testicular redox imbalance leading to enhanced apoptosis via a p53 dependent Bax-caspase-3 pathway with severity increasing over time.

Plain English Summary

Summary written for general audiences

Twelve-week old male mice were exposed to 2.45 GHz microwave radiation at 0.0248 mW/cm2 power density and 0.0146 W/kg SAR for two hours daily over 15, 30, and 60 days. Researchers evaluated testicular histology, serum testosterone, ROS, NO, MDA, antioxidant enzymes, and apoptotic protein expression. Exposure induced testicular redox imbalance that enhanced apoptosis via a p53 dependent Bax-caspase-3 pathway with severity increasing with exposure duration.

Why This Matters

The study aimed to investigate the detailed pathway of testicular apoptosis induced by free radical load and redox imbalance from 2.45 GHz microwave radiation and how severity changes with longer exposure. Previous reports had suggested oxidative and nitrosative stress from this radiation affects male reproduction but the molecular mechanism was not yet elucidated.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study.

Cite This Study
Unknown (2018). Shahin S, Singh SP, Chaturvedi CM 2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax-caspase-3 mediated pathway.
Show BibTeX
@article{shahin_s_singh_sp_chaturvedi_cm_245_ghz_microwave_radiation_induced_oxidative_and_nitrosative_stress_mediated_testicular_apoptosis_involvement_of_a_p53_dependent_bax_caspase_3_mediated_pathway_ce2590,
  author = {Unknown},
  title = {Shahin S, Singh SP, Chaturvedi CM 2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax-caspase-3 mediated pathway},
  year = {2018},
  doi = {10.1002/tox.22578},
  
}
DOI: 10.1002/tox.22578PubMed: 29968967

Quick Questions About This Study

Twelve-week old male mice were exposed to 2.45 GHz microwave radiation at 0.0248 mW/cm2 power density and 0.0146 W/kg SAR for two hours daily over 15, 30, and 60 days.
Researchers evaluated testicular histology, serum testosterone, ROS, NO, MDA, antioxidant enzymes, and expression of pro-apoptotic and anti-apoptotic proteins including p53, Bax, Bcl-2, Bcl-xL, cytochrome-c, caspase-3, and PARP-1.
Exposure induced testicular redox imbalance that enhanced apoptosis via a p53 dependent Bax-caspase-3 pathway with severity increasing with exposure duration.
The study aimed to investigate the detailed pathway of testicular apoptosis induced by free radical load and redox imbalance from 2.45 GHz microwave radiation and how severity changes with longer exposure.
Previous reports suggested that 2.45 GHz microwave irradiation induced oxidative and nitrosative stress that adversely affects male reproductive function but the detailed molecular mechanism was not yet elucidated.