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Significant differences in the effects of magnetic field exposure on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in two substrains of Sprague-Dawley rats

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Authors not listed · 2004

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Magnetic field exposure significantly increased mammary tumor development and growth in SD1 rats but not in SD2 rats, indicating that genetic background plays a pivotal role in the effects of magnetic field exposure.

Plain English Summary

Summary written for general audiences

Researchers compared two Sprague-Dawley substrains, SD1 and SD2, for magnetic field effects on cell proliferation, susceptibility to DMBA-induced mammary cancer, and tumor development in the DMBA model. The SD1 substrain was considered MF-sensitive and was compared with SD2 from the same breeder. Magnetic field exposure significantly increased mammary tumor development and growth in SD1 rats but not in SD2 rats. No enhanced cell proliferation was determined after magnetic field exposure in SD2 rats, unlike in SD1 rats. The researchers concluded that genetic background plays a pivotal role in magnetic field exposure effects.

Why This Matters

Previous work by the same group showed that 50-Hz magnetic fields at microtesla flux densities enhance mammary gland tumor development and growth in the DMBA model of breast cancer in female Sprague-Dawley rats. That earlier work also found that magnetic field exposure results in enhanced proliferative activity of the mammary epithelium of SD rats. A similar study by Battelle in the United States found no evidence for a cocarcinogenic or tumor-promoting effect of magnetic field exposure in the DMBA model in SD rats. The U.S. rats were much more susceptible to DMBA than the rats used in the researchers' studies. The authors suggest that different strains or substrains of rats may serve to evaluate the genetic factors underlying sensitivity to cocarcinogenic or tumor-promoting effects of magnetic field exposure.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study.

Cite This Study
Unknown (2004). Significant differences in the effects of magnetic field exposure on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in two substrains of Sprague-Dawley rats.
Show BibTeX
@article{significant_differences_in_the_effects_of_magnetic_field_exposure_on_712_dimethylbenzaanthracene_induced_mammary_carcinogenesis_in_two_substrains_of_sprague_dawley_rats_ce1488,
  author = {Unknown},
  title = {Significant differences in the effects of magnetic field exposure on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in two substrains of Sprague-Dawley rats},
  year = {2004},
  doi = {10.1158/0008-5472.CAN-03-2808},
  
}
DOI: 10.1158/0008-5472.CAN-03-2808PubMed: 14729631

Quick Questions About This Study

The study compared two Sprague-Dawley substrains, SD1 and SD2, for magnetic field effects on cell proliferation, susceptibility to DMBA-induced mammary cancer, and tumor development in the DMBA model.
Magnetic field exposure significantly increased mammary tumor development and growth in SD1 rats but not in SD2 rats.
No enhanced cell proliferation was determined after magnetic field exposure in SD2 rats, in contrast to SD1 rats.
The researchers concluded that genetic background plays a pivotal role in effects of magnetic field exposure.
A similar U.S. study found no evidence for a cocarcinogenic or tumor-promoting effect of magnetic field exposure in the DMBA model, and the U.S. rats were much more susceptible to DMBA than the rats used in the researchers' studies.