The influence of 1.2 microT, 60 Hz magnetic fields on melatonin- and tamoxifen-induced inhibition of MCF-7 cell growth
Authors not listed · 2001
A 1.2 microT, 60 Hz magnetic field blocked melatonin's inhibitory effect and reduced tamoxifen's inhibitory effect on MCF-7 cell growth.
Plain English Summary
Researchers independently replicated a study testing whether a 1.2 microT, 60 Hz magnetic field alters the effects of melatonin and tamoxifen on MCF-7 human breast cancer cells. In the melatonin experiment, repeated three times, melatonin reduced cell numbers by 16.7% after seven days, but this reduction disappeared when cells were exposed to the magnetic field. In the tamoxifen experiment, repeated nine times, tamoxifen reduced cell growth by 18.6% and 25% on days six and seven without the field, but only by 8.7% and 13.1% with the field. The results were consistent with the original findings of Harland and Liburdy.
Why This Matters
Cells were harvested at selected times and enumerated without knowledge of treatment. Treatment was applied continuously until the assays were performed. The authors noted that constructive communication with the original investigators was critical to the successful replication.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{the_influence_of_12_microt_60_hz_magnetic_fields_on_melatonin_and_tamoxifen_induced_inhibition_of_mcf_7_cell_growth_ce1536,
author = {Unknown},
title = {The influence of 1.2 microT, 60 Hz magnetic fields on melatonin- and tamoxifen-induced inhibition of MCF-7 cell growth},
year = {2001},
doi = {10.1002/1521-186X(200102)22:2<122::AID-BEM1015>3.0.CO;2-V},
}