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The Influence of Electric Current on Bone Regeneration In Vivo

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L. S. Lavine, I. Lustrin, M. H. Shamos, M. L. Moss · 1971

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This 1971 study proved bones respond to electrical stimulation, showing our bodies are electrical systems affected by external fields.

Plain English Summary

Summary written for general audiences

Researchers in 1971 studied how direct electrical current affects bone healing and growth in laboratory animals. They found that electrical stimulation appears to influence bone regeneration, building on the discovery that bones naturally generate electrical signals when stressed. This early work helped establish the scientific foundation for using electrical therapy in orthopedic medicine.

Why This Matters

This 1971 study represents a pivotal moment in our understanding of bioelectricity and healing. The researchers discovered that bones respond to electrical stimulation in ways that promote regeneration, essentially proving that our bodies are fundamentally electrical systems. What makes this research particularly significant is how it demonstrates that even very low-level electrical fields can have profound biological effects. The study used just 1.4 volts with a resistor to create their experimental setup - that's less electrical current than what flows through many of the wireless devices we use daily. This raises important questions about how the constant electromagnetic fields from our modern technology might be affecting our body's natural electrical processes, including bone health and healing.

Figures from the Original Paper

Diagrams extracted from the original research document.

diagramPage 2 - Figure 1. Diagram of experimental unit.
diagramPage 3 - AI-described figure: Figure 2. Circuit completed through microampere meter; showing method of monitoring current.
diagramPage 4 - Figure 4. X-ray showing platinum electrodes in situ in the cortex of the femur.
diagramPage 5 - Figure 5. Gross comparison of the 'experimental defect' in three-week experimental and control animals.
diagramPage 7 - AI-described figure: Figure 7. A control section three weeks postoperative showing the lumen of the cavity filled with loose tissue and some evidence of postoperative reactive osteogenesis.
diagramPage 8 - Figure 8. This specimen, three weeks experimental, differs from that shown in Figure 7 in that the defect is filled with a mass of trabecular bone which seems to be continuous with similar tissue type found within the medullary cavity.
photoPage 9 - Figure 9. A good degree of bony repair has filled the experimental cortical defect in this specimen after three weeks of application of direct current.
photoPage 10 - AI-described figure: A microscopic image showing advanced bone repair in a specimen after three weeks of experimental treatment.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
L. S. Lavine, I. Lustrin, M. H. Shamos, M. L. Moss (1971). The Influence of Electric Current on Bone Regeneration In Vivo.
Show BibTeX
@article{the_influence_of_electric_current_on_bone_regeneration_in_vivo_g7402,
  author = {L. S. Lavine and I. Lustrin and M. H. Shamos and M. L. Moss},
  title = {The Influence of Electric Current on Bone Regeneration In Vivo},
  year = {1971},
  
  
}
No DOI on file for this study.

Quick Questions About This Study

Researchers used a simple 1.4 volt mercury battery connected with a 174K resistor to create direct current for their bone studies. This low voltage setup was designed to mimic natural electrical processes in bone tissue.
Bones create electrical potentials through a piezoelectric effect when mechanical stress causes shearing forces on bone collagen. This natural bioelectricity appears to guide bone architecture and structural integrity during growth and repair processes.
Direct current was selected because it more closely mimics the natural electrical potentials that bones generate during stress and healing. The researchers found DC effects on bone physiology particularly interesting for understanding orthopedic healing mechanisms.
This study helped establish that electrical stimulation could influence bone regeneration, laying groundwork for modern electrical bone healing therapies. It proved that bones are electrically active tissues that respond to external electrical fields.
When bones experience mechanical stress, the collagen fibers generate electrical potentials through piezoelectric effects. These stress-induced electrical signals appear to direct bone remodeling and help maintain structural integrity during healing and growth.