The protective role of spermine against male reproductive aberrations induced by exposure to electromagnetic field - An experimental investigation in the rat
Authors not listed · 2019
Rat exposure to 900 MHz EMF for 8 weeks impaired sperm quality, and spermine administration prevented these alterations.
Plain English Summary
Researchers exposed rats to 900 MHz EMF for 2 hours daily over 8 weeks and measured effects on male reproductive parameters. EMF exposure significantly decreased sperm count, viability and motility and increased sperm deformities. EMF-exposed rats showed significant reductions in serum inhibin B and testosterone along with elevated activin A, follicle-stimulating hormone, luteinizing hormone and estradiol concentrations. Testicular StAR protein, c-kit mRNA expression, and activities of 3β- and 17β-hydroxysteroid dehydrogenases were significantly attenuated after EMF exposure. Spermine administered at 2.5 mg/Kg/day intraperitoneally for 8 weeks prevented EMF-induced alterations in sperm and hormone profiles, StAR and c-kit expression, and androgenic enzyme activities.
Why This Matters
EMF-exposed rats showed testicular DNA damage as indicated by elevated comet parameters. Spermine hampered EMF-induced oxidative, inflammatory, apoptotic and DNA perturbations. Histological and histomorphometric analysis of the testes supported all biochemical findings.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{the_protective_role_of_spermine_against_male_reproductive_aberrations_induced_by_exposure_to_electromagnetic_field_an_experimental_investigation_in_the_rat_ce2591,
author = {Unknown},
title = {The protective role of spermine against male reproductive aberrations induced by exposure to electromagnetic field - An experimental investigation in the rat},
year = {2019},
doi = {10.1016/j.taap.2019.03.009},
}