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Effect of low-level 1800 MHz radiofrequency radiation on the rat sciatic nerve and the protective role of paricalcitol.

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Comelekoglu U, Aktas S, Demirbag B, Karagul MI, Yalin S, Yildirim M, Akar A, Korunur Engiz B, Sogut F, Ozbay E. · 2018

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Rats exposed to 1,800 MHz RF radiation for 1 hour daily over 4 weeks showed nerve damage including reduced amplitude, prolonged latency, increased MDA and catalase activity, and myelin degeneration, which was partially reduced by paricalcitol.

Plain English Summary

Summary written for general audiences

Researchers divided rats into four groups: control, paricalcitol only, RF exposure only, and RF plus paricalcitol. Rats in the RF groups were exposed to 1,800 MHz RF radiation for 1 hour per day for 4 weeks. RF exposure caused significant reduction in nerve signal amplitude, prolonged latency, increased malondialdehyde levels, increased catalase activity, and degeneration of myelinated nerve fibers. Paricalcitol administration partially ameliorated these neuropathic changes.

Why This Matters

Control and paricalcitol-only rats were kept under identical conditions without RF exposure. Paricalcitol was administered at 0.2 μg/kg/day three times per week for 4 weeks. The study evaluated nerve compound action potential amplitude and latency, catalase activity, malondialdehyde levels, and ultrastructural changes in the sciatic nerve.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 1800 MHz Duration: 1 h per day for 4 weeks

Study Details

The present study was designed to investigate the effects of 1,800 MHz RF radiation and the protective role of paricalcitol on the rat sciatic nerve.

Rats were divided into four groups as control, paricalcitol, RF, and RF + paricalcitol. In RF groups...

In the RF group, a significant reduction in amplitude, prolongation in latency, an increase in the M...

Cite This Study
Comelekoglu U, Aktas S, Demirbag B, Karagul MI, Yalin S, Yildirim M, Akar A, Korunur Engiz B, Sogut F, Ozbay E. (2018). Effect of low-level 1800 MHz radiofrequency radiation on the rat sciatic nerve and the protective role of paricalcitol. Bioelectromagnetics. 39(8):631-643, 2018.
Show BibTeX
@article{u_2018_effect_of_lowlevel_1800_1626,
  author = {Comelekoglu U and Aktas S and Demirbag B and Karagul MI and Yalin S and Yildirim M and Akar A and Korunur Engiz B and Sogut F and Ozbay E.},
  title = {Effect of low-level 1800 MHz radiofrequency radiation on the rat sciatic nerve and the protective role of paricalcitol.},
  year = {2018},
  doi = {10.1002/bem.22149},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.22149},
}
DOI: 10.1002/bem.22149

Cited By (11 papers)

Quick Questions About This Study

Rats were exposed to 1,800 MHz RF radiation for 1 hour per day for 4 weeks.
RF exposure significantly reduced nerve signal amplitude, prolonged latency, increased malondialdehyde levels, increased catalase activity, and caused degeneration of myelinated nerve fibers.
The neuropathic changes were partially ameliorated with paricalcitol administration.
Rats received 0.2 μg/kg/day paricalcitol three times per week for 4 weeks.
The study measured amplitude and latency of nerve compound action potentials, catalase activity, malondialdehyde levels, and ultrastructural changes in the sciatic nerve.