Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke
Urnukhsaikhan E, Mishig-Ochir T, Kim S-C, Park J-K, Seo Y-K · 2017
C57B6 mice exposed to LF-PEMF at 60 Hz and 10 mT after photothrombotic occlusion showed a neuroprotective effect.
Plain English Summary
Researchers exposed C57B6 mice to LF-PEMF at 60 Hz and 10 mT after inducing ischemic stroke via photothrombotic occlusion. They measured the BDNF/TrkB/Akt signaling pathway, pro-apoptotic and pro-survival protein and gene expressions, inflammatory mediators, and performed behavioral tests. LF-PEMF treatment promoted activation of the BDNF/TrkB/Akt signaling pathway. Pro-survival proteins increased significantly, while pro-apoptotic proteins and inflammatory mediators decreased. The results demonstrated a neuroprotective effect of LF-PEMF exposure after ischemic stroke in mice during recovery.
Why This Matters
The researchers noted that low frequency-pulsed electromagnetic fields affect many biological processes but their fundamental mechanisms remain unclear. The study aimed to investigate the effect of LF-PEMFs on neuroprotection after ischemic stroke.
Show BibTeX
@article{urnukhsaikhan_e_mishig_ochir_t_kim_s_c_park_j_k_seo_y_k_ce4575,
author = {Urnukhsaikhan E and Mishig-Ochir T and Kim S-C and Park J-K and Seo Y-K},
title = {Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke},
year = {2017},
}