Melatonin ameliorates RF-EMR-induced reproductive damage by inhibiting ferroptosis through Nrf2 pathway activation
Wang J, Dong J, Xu Q, Yan S, Wang H, Lei H, Ma X, Yang T, Wang K, Li Z, Wang X · 2025
Melatonin mitigated RF-EMR-induced oxidative harm and ferroptosis in mouse testes and inhibited ROS production by stimulating the Nrf2 pathway via MT1/MT2 receptors.
Plain English Summary
Researchers exposed male mice to 2.45 GHz RF-EMR at 2.5 W/m2 for 8 weeks, which induced ferroptosis and oxidative stress in testicular tissue and reduced sperm quality. Melatonin administration reduced the oxidative damage and ferroptosis in the testes of exposed mice. The protective effect was mediated by melatonin stimulating the Nrf2 signaling pathway through MT1/MT2 receptors, inhibiting ROS production and ferroptosis.
Why This Matters
The authors concluded that melatonin could potentially improve RF-EMR-induced reproductive damage in male mice by blocking ferroptosis through activation of the Nrf2 pathway. Exposure to RF-EMR at 2.45 GHz with a power density of 2.5 W/m2 and SAR of 0.125-0.5 W/kg induced ferroptosis and oxidative stress in testicular tissue, leading to a decrease of sperm quality in male mice.
Show BibTeX
@article{wang_j_dong_j_xu_q_yan_s_wang_h_lei_h_ma_x_yang_t_wang_k_li_z_wang_x_ce2636,
author = {Wang J and Dong J and Xu Q and Yan S and Wang H and Lei H and Ma X and Yang T and Wang K and Li Z and Wang X},
title = {Melatonin ameliorates RF-EMR-induced reproductive damage by inhibiting ferroptosis through Nrf2 pathway activation},
year = {2025},
}