Modulation of Low-Frequency Pulsed Magnetic Field on Hippocampal Neural Oscillation in Depression Rats
Wang L, Yang J, Wang F, Zhou P, Wang K , Ming D · 2018
Low-frequency pulsed magnetic field at 1 Hz and 20 mT for 14 days relieved depression-like behaviors and improved neural oscillation synchronization in stressed rats.
Plain English Summary
Researchers established a depression rat model using chronic unpredictable stress. Rats were exposed to low-frequency pulsed magnetic field at 1 Hz and 20 mT for 14 days, one hour per day. They assessed behavior with the elevated plus-maze test and recorded hippocampal local field potentials. Analysis used sample entropy, phase locked value, and phase-amplitude coupling modulation index. LFPMF significantly relieved depression-like behaviors and improved identical-frequency synchronization and theta-gamma phase-amplitude coupling.
Why This Matters
Most studies had focused on high-frequency TMS, and little was known about low-frequency TMS in depression treatment. The potential electroneurophysiology mechanisms of TMS on brain function were poorly understood. The researchers concluded that antidepressive-like effects might be linked to improvement in neural oscillation.
Show BibTeX
@article{wang_l_yang_j_wang_f_zhou_p_wang_k_ming_d_ce4585,
author = {Wang L and Yang J and Wang F and Zhou P and Wang K and Ming D},
title = {Modulation of Low-Frequency Pulsed Magnetic Field on Hippocampal Neural Oscillation in Depression Rats},
year = {2018},
}