Fifty-Hertz electromagnetic fields facilitate the induction of rat bone mesenchymal stromal cells to differentiate into functional neurons
Bai WF, Xu WC, Feng Y, Huang H, Li XP, Deng CY, Zhang MS. · 2013
View Original AbstractExposing rat bone marrow stromal cells to 50-Hz electromagnetic fields facilitated their differentiation into functional neurons in the lab.
Plain English Summary
Researchers divided rat bone marrow stromal cells into three groups: one treated with electromagnetic fields, one induced without fields, and a control group. The cells in the EMF group expressed neuron-specific markers and genes, formed synaptic junctions, and pulsed excitatory postsynaptic currents. The researchers suggested that EMF appears to be a promising clinical option for stem cell transplantation therapies to combat central nervous system diseases.
Why This Matters
The study was conducted in vitro, exploring the efficacy of EMF on the induction of rat BMSC differentiation into neurons. The electromagnetic field exposure was set at a frequency of 50 Hz, a magnetic induction of 5 mT, for 60 minutes per day over 12 days. Researchers used several measurement methods, including confocal microscopy for cell shape, PCR for gene expression, and patch-clamp recording for postsynaptic currents. Flow cytometry showed that the proportion of cells in the G0-G1 phase gradually decreased under EMF treatment, while the S-phase ratio increased, and more cells expressed neuronal markers.
Exposure Details
- Magnetic Field
- 5 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 60 min/day for up to 12 days
Exposure Context
This study used 5 mT for magnetic fields:
- 250Kx above the Building Biology guideline of 0.2 mG
- 50Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In the present study, we explored the efficacy of EMF on the induction of rat BMSC differentiation into neurons in vitro.
First, rat BMSC were induced in a nerve cell culture environment and divided into three groups: an E...
The results indicated that EMF can facilitate BMSC differentiation into neural cells, which expresse...
Given that a noninvasive treatment of 50-Hz EMF could significantly facilitate BMSC to differentiate into functional neurons, EMF appears to be a promising clinical option for stem cell transplantation therapies to combat central nervous system diseases.
Show BibTeX
@article{wf_2013_fiftyhertz_electromagnetic_fields_facilitate_220,
author = {Bai WF and Xu WC and Feng Y and Huang H and Li XP and Deng CY and Zhang MS.},
title = {Fifty-Hertz electromagnetic fields facilitate the induction of rat bone mesenchymal stromal cells to differentiate into functional neurons},
year = {2013},
url = {https://www.sciencedirect.com/science/article/abs/pii/S1465324913004489},
}