Extremely low-frequency electromagnetic field exposure during chronic morphine treatment strengthens downregulation of dopamine D2 receptors in rat dorsal hippocampus after morphine withdrawal.
Wang X, Liu Y, Lei Y, Zhou D, Fu Y, Che Y, Xu R, Yu H, Hu X, Ma Y. · 2008
View Original AbstractELF-EMF exposure during morphine treatment further reduced dopamine D2 receptor density in rat dorsal hippocampus after morphine withdrawal.
Plain English Summary
Researchers exposed rats to extremely low-frequency electromagnetic fields (20 Hz, 14 mT) for one hour per day before daily morphine injections for 12 days, then measured dopamine D2 receptor density in the dorsal hippocampus during withdrawal. Morphine withdrawal alone significantly lowered D2 receptor density compared to saline controls, and ELF-EMF exposure during morphine treatment further reduced receptor density on the first and third withdrawal days. In both groups, D2 receptor density tended to recover as the number of withdrawal days increased.
Why This Matters
The study used immunohistochemistry to measure D2 receptor density at three time points: the 1st, 3rd, and 5th days of morphine withdrawal. A saline control group was sham-exposed for the same period, providing a baseline for comparing receptor levels. The researchers suggest that dorsal hippocampal D2 receptors are sensitive to morphine withdrawal and that ELF-EMF exposure during morphine treatment potentiates this effect.
Exposure Details
- Magnetic Field
- 14 mT
- Source/Device
- 20 Hz
- Exposure Duration
- 1 h per day,once daily for 12 days
Exposure Context
This study used 14 mT for magnetic fields:
- 700Kx above the Building Biology guideline of 0.2 mG
- 140Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The aim of this study was to investigate the effect of extremely low-frequency electromagnetic field (ELF-EMF) exposure during morphine treatment on dopamine D2 receptor (D2R) density in the rat dorsal hippocampus following withdrawal.
Rats were exposed to ELF-EMF (20 Hz, 14 mT) or sham exposed for 1 h per day before injection of morp...
The results showed that the density of D2Rs in sham-exposed morphine-treated rats on the 1st and 3rd...
Show BibTeX
@article{x_2008_extremely_lowfrequency_electromagnetic_field_310,
author = {Wang X and Liu Y and Lei Y and Zhou D and Fu Y and Che Y and Xu R and Yu H and Hu X and Ma Y.},
title = {Extremely low-frequency electromagnetic field exposure during chronic morphine treatment strengthens downregulation of dopamine D2 receptors in rat dorsal hippocampus after morphine withdrawal.},
year = {2008},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0304394008000384},
}