STAT3 signalling pathway is involved in the activation of microglia induced by 2.45 GHz electromagnetic fields.
Hao Y, Yang X, Chen C, Yuan-Wang, Wang X, Li M, Yu Z. · 2010
View Original AbstractWiFi-frequency EMF directly activates brain immune cells through inflammatory pathways, potentially contributing to neuroinflammation.
Plain English Summary
Researchers exposed brain immune cells called microglia to 2.45 GHz electromagnetic fields (the same frequency used in WiFi and microwaves) and found that this radiation activated inflammatory pathways in the cells. The EMF exposure triggered specific molecular changes that led to increased production of inflammatory proteins and nitric oxide. This matters because activated microglia contribute to brain inflammation, which is linked to neurological problems and brain diseases.
Why This Matters
This study reveals a concerning mechanism by which everyday EMF exposures may trigger brain inflammation. The researchers identified the specific STAT3 signaling pathway through which 2.45 GHz radiation activates microglia, the brain's immune cells. When microglia become chronically activated, they can contribute to neuroinflammation associated with conditions ranging from cognitive decline to neurodegenerative diseases. The 2.45 GHz frequency tested here is identical to what your WiFi router, microwave oven, and many wireless devices emit daily. What makes this research particularly significant is that it demonstrates a clear biological mechanism, not just correlation. The science shows that EMF exposure doesn't just coincidentally occur alongside cellular changes - it directly triggers the inflammatory cascade through identifiable molecular pathways.
Exposure Information
Specific exposure levels were not quantified in this study. The study examined exposure from: 2.45 GHz
Study Details
The aim of the present work was to investigate the activation of microglia and involvement of signal transducer and activator of transcription 3 (STAT3) in microglia activation after 2.45 GHz electromagnetic fields (EMF) exposure.
In this study, murine N9 microglial cells were exposed to 2.45 GHz EMF, the protein expressions of S...
A significant increase of STAT3 DNA-binding ability was noted after exposure. Consistent with this, ...
These results provide evidence that EMF exposure can initiate the activation of microglia cells and STAT3 signalling involves in EMF-induced microglial activation.
Show BibTeX
@article{y_2010_stat3_signalling_pathway_is_2156,
author = {Hao Y and Yang X and Chen C and Yuan-Wang and Wang X and Li M and Yu Z.},
title = {STAT3 signalling pathway is involved in the activation of microglia induced by 2.45 GHz electromagnetic fields.},
year = {2010},
url = {https://pubmed.ncbi.nlm.nih.gov/20070213/},
}