Evidence of bystander effect induced by radiofrequency radiation in a human neuroblastoma cell line
Zeni O, Romeo S, Sannino A, Palumbo R, Scarfì MR · 2021
Culture medium from SH-SY5Y neuroblastoma cells exposed to 1950 MHz RF reduced menadione-induced DNA damage in non-exposed cells, indicating a bystander effect.
Plain English Summary
Researchers exposed SH-SY5Y neuroblastoma cells to 1950 MHz radiofrequency fields. Medium from the exposed cells reduced menadione-induced DNA damage in recipient non-exposed cells (P<0.05, comet assay). Direct exposure to the same RF conditions also reduced DNA damage (P<0.05) and increased extracellular hsp70 without changing intracellular hsp70.
Why This Matters
The authors concluded that RF exposure exerts a protective effect against menadione-induced DNA damage in both directly and indirectly exposed cells and proposed the hsp70 pathway as a candidate mechanism. Earlier work by the same group showed that RF fields can reduce DNA damage from later genotoxic treatment, resembling an adaptive response.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{zeni_o_romeo_s_sannino_a_palumbo_r_scarf_mr_ce3116,
author = {Zeni O and Romeo S and Sannino A and Palumbo R and Scarfì MR},
title = {Evidence of bystander effect induced by radiofrequency radiation in a human neuroblastoma cell line},
year = {2021},
doi = {10.1016/j.envres.2021.110935},
}